Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase (Q27617894)

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4 December 2019

title

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase (English)

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4 December 2019

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4 December 2019

A M Aronov

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4 December 2019

S Suresh

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4 December 2019

F S Buckner

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4 December 2019

W C Van Voorhis

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4 December 2019

C L Verlinde

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4 December 2019

W G Hol

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4 December 2019

M H Gelb

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4 December 2019

language of work or name

English

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publication date

1 April 1999

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Proceedings of the National Academy of Sciences of the United States of America

4 December 2019

published in

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4 December 2019

volume

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4 December 2019

issue

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4 December 2019

page(s)

4273-4278

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Crystal Structure of Glycosomal Glyceraldehyde-3-phosphate Dehydrogenase from Leishmania mexicana: Implications for Structure-Based Drug Design and a New Position for the Inorganic Phosphate Binding Site

4 December 2019

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Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase

20 March 2017

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Metabolic compartmentation in African trypanosomes

21 January 2018

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Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

29 September 2017

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Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs.

29 September 2017

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The treatment of human African trypanosomiasis

29 September 2017

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Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

29 September 2017

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The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei. Kinetic properties and comparison with homologous enzymes

29 September 2017

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QXP: powerful, rapid computer algorithms for structure-based drug design.

29 September 2017

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A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay

2 June 2018

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Cultivation of Trypanosoma brucei sspp. in semi-defined and defined media

2 June 2018

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Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects

2 June 2018

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Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism

2 June 2018

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Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.

2 June 2018

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Refined 3.2 A structure of glycosomal holo glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei

21 January 2018

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Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.

21 January 2018

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Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.

21 January 2018

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Synthesis and Conformational Analysis of 2?-Deoxy-2?-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

21 January 2018

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Aerobic glucose fermentation by Trypanosoma cruzi axenic culture amastigote-like forms during growth and differentiation to epimastigotes

21 January 2018

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Prospects for antiparasitic drugs. The case of Trypanosoma brucei, the causative agent of African sleeping sickness

21 January 2018

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Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase: structure, catalytic mechanism and targeted inhibitor design

21 January 2018

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N6-Substituted adenosines. Synthesis, biological activity, and some structure-activity relations

21 January 2018

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A novel method for phosphorylation of nucleosides to 5′-nucleotides

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/10200252

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12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.96.8.4273

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4 December 2019

0 references

1 reference

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4 December 2019

PubMed publication ID

10200252

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