An essential function of the extreme C-terminus of MDM2 can be provided by MDMX (Q24328822)

From Wikidata

Jump to navigation Jump to search

scientific article

edit

Language	Label	Description	Also known as
English	An essential function of the extreme C-terminus of MDM2 can be provided by MDMX	scientific article

Statements

instance of

scholarly article

0 references

title

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX (English)

0 references

main subject

MDM2 proto-oncogene

1 reference

stated in

GOA release 2020-03-11

identical protein binding

1 reference

stated in

GOA release 2020-03-11

author

Karen Vousden

series ordinal

3

object named as

Karen H Vousden

0 references

author name string

Stjepan Uldrijan

series ordinal

1

0 references

Willem-Jan Pannekoek

series ordinal

2

0 references

language of work or name

English

0 references

publication date

10 January 2007

0 references

published in

The EMBO Journal

0 references

volume

26

0 references

issue

1

0 references

page(s)

102-12

0 references

cites work

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

MDMX: a novel p53-binding protein with some functional properties of MDM2

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Surfing the p53 network

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

6 April 2017

Posttranslational modification of MDM2

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

MDM2 interacts with MDMX through their RING finger domains

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

19 March 2017

p53 ubiquitination: Mdm2 and beyond

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

7 April 2017

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

7 April 2017

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

The central region of HDM2 provides a second binding site for p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

INK4a/ARF: a multifunctional tumor suppressor locus

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Small molecule antagonists of the MDM2 oncoprotein as anticancer agents

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

HDM2 phosphorylation by MAPKAP kinase 2.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

DNA damage-induced MDMX degradation is mediated by MDM2.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

MDM2 promotes ubiquitination and degradation of MDMX

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Critical contribution of the MDM2 acidic domain to p53 ubiquitination

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Critical role for a central part of Mdm2 in the ubiquitylation of p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Activation of the p53 tumor suppressor protein

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Regulation and function of the p53 tumor suppressor protein

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

MdmX protects p53 from Mdm2-mediated degradation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

The MDM2 gene amplification database

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

27 September 2017

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

30 May 2018

Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782374

retrieved

29 November 2018

Metal and RNA binding properties of the hdm2 RING finger domain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17159902

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RING domain of Mdm2 can inhibit cell proliferation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17159902

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hdmx stabilizes Mdm2 and p53

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17159902

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17159902

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/SJ.EMBOJ.7601469

0 references

PMC publication ID

1782374

0 references

PubMed publication ID

17159902

0 references

ResearchGate publication ID

6639609

0 references

 

Sitelinks

Wikipedia(0 entries)

edit

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q24328822&oldid=1398347684"