Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR (Q27647018)

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English	Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR	scientific article

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3 January 2020

Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR (English)

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3 January 2020

Václav Veverka

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3 January 2020

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T Crabbe

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3 January 2020

I Bird

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3 January 2020

G Lennie

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3 January 2020

F W Muskett

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3 January 2020

R J Taylor

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3 January 2020

M D Carr

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6 August 2007

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3 January 2020

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3 January 2020

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3 January 2020

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3 January 2020

585-595

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3 January 2020

Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Characterization of the FKBP.rapamycin.FRB ternary complex

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

An expanding role for mTOR in cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Upstream and downstream of mTOR

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

The FRB domain of mTOR: NMR solution structure and inhibitor design

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

TOR signaling in growth and metabolism

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210693

21 April 2017

Growing roles for the mTOR pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 April 2017

Key cancer cell signal transduction pathways as therapeutic targets.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Phospholipase D confers rapamycin resistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Localizing the NADP+ binding site on the MurB enzyme by NMR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Regulation of mTOR by phosphatidic acid?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Improved efficiency of protein structure calculations from NMR data using the program DIANA with redundant dihedral angle constraints.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Use of very long-distance NOEs in a fully deuterated protein: an approach for rapid protein fold determination.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

mTOR signaling: implications for cancer and anticancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

mTOR and cancer: reason for dancing at the crossroads?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

NMR assignment of the mTOR domain responsible for rapamycin binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Mapping the binding site for matrix metalloproteinase on the N-terminal domain of the tissue inhibitor of metalloproteinases-2 by NMR chemical shift perturbation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

PA promoted to manager

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

21 January 2018

Model building and refinement practice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210693

7 January 2021

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10.1038/SJ.ONC.1210693

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3 January 2020

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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3 January 2020

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