Phospholipase D confers rapamycin resistance in human breast cancer cells (Q44482361)

3 December 2017

title

Phospholipase D confers rapamycin resistance in human breast cancer cells (English)

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3 December 2017

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Yuhong Chen

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3 December 2017

Yang Zheng

series ordinal

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3 December 2017

David A Foster

series ordinal

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3 December 2017

language of work or name

English

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publication date

1 June 2003

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3 December 2017

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3 December 2017

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3 December 2017

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3 December 2017

page(s)

3937-3942

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

3 December 2017

cites work

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells

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Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

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Ras mediates the activation of phospholipase D by v-Src

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Involvement of Ral GTPase in v-Src-induced phospholipase D activation

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Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling

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Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2.

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Autocrine TGFbeta supports growth and survival of human breast cancer MDA-MB-231 cells

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Estrogen regulation of cell cycle progression in breast cancer cells

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Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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TOR, a central controller of cell growth

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Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

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Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells

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Identifiers

DOI

10.1038/SJ.ONC.1206565

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Dimensions Publication ID

3 December 2017

1014785322

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