The roles of PIKE in tumorigenesis (Q27023876)

Acta Pharmacologica Sinica

1 August 2013

9 references

3 April 2019

30 June 2019

28 September 2019

20 November 2019

28 November 2019

13 September 2020

18 September 2020

4 November 2020

1 December 2020

9 references

3 April 2019

30 June 2019

28 September 2019

20 November 2019

28 November 2019

13 September 2020

4 November 2020

1 December 2020

1 reference

1 reference

991-7

1 reference

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

8 references

3 April 2019

30 June 2019

28 September 2019

20 November 2019

28 November 2019

13 September 2020

4 November 2020

The association of phosphoinositide 3‐kinase enhancer A with hepatic insulin receptor enhances its kinase activity

1 December 2020

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PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development

21 March 2017

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Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

21 March 2017

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Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

21 March 2017

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Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings

21 March 2017

1 reference

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The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase

21 March 2017

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PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

21 March 2017

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GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins

21 March 2017

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Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N

21 March 2017

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Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase

21 March 2017

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Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms

21 March 2017

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PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

21 March 2017

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The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: biology and therapeutic relevance

21 March 2017

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21 March 2017

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p53RDL1 regulates p53-dependent apoptosis

21 January 2018

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Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

21 March 2017

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Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling

21 March 2017

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Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration

21 March 2017

1 reference

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Fyn: a novel molecular target in cancer

21 March 2017

1 reference

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PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion

21 March 2017

1 reference

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Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival

21 March 2017

1 reference

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Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas

21 March 2017

1 reference

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Netrin-1 and its receptors in tumorigenesis

21 March 2017

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PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion

21 March 2017

1 reference

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Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers

21 March 2017

1 reference

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Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1

21 March 2017

1 reference

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Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration

21 March 2017

1 reference

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Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1

21 March 2017

1 reference

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PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells

9 May 2017

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IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.

9 May 2017

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Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.

28 September 2017

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JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer

28 September 2017

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Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy

28 September 2017

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28 September 2017

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Regulation of inflammatory breast cancer cell invasion through Akt1/PKBα phosphorylation of RhoC GTPase

28 September 2017

1 reference

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Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation

28 September 2017

1 reference

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

28 September 2017

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Tools for protein-protein interaction network analysis in cancer research.

28 September 2017

1 reference

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Essential role of PIKE GTPases in neuronal protection against excitotoxic insults

28 September 2017

1 reference

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Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex

28 September 2017

1 reference

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Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner

28 September 2017

1 reference

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The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis

28 September 2017

1 reference

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Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis

28 September 2017

1 reference

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Automated network analysis identifies core pathways in glioblastoma

28 September 2017

1 reference

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Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

28 September 2017

1 reference

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Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance

28 September 2017

1 reference

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Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

28 September 2017

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Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling

28 September 2017

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GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression.

28 September 2017

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A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling

28 September 2017

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Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion

28 September 2017

1 reference

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Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression

28 September 2017

1 reference

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The netrin receptor UNC5B promotes angiogenesis in specific vascular beds

28 September 2017

1 reference

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Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion.

28 September 2017

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Netrin-1 induces proliferation of Schwann cells through Unc5b receptor

28 September 2017

1 reference

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PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death

28 September 2017

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Pleckstrin homology (PH) domains and phosphoinositides

28 September 2017

1 reference

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Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer

28 September 2017

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Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

28 September 2017

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Pike tyrosine phosphorylation regulates its apoptotic cleavage during programmed cell death

28 September 2017

1 reference

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Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis?

28 September 2017

1 reference

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Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

28 September 2017

1 reference

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The RET proto-oncogene: a potential target for molecular cancer therapy.

28 September 2017

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PIKE GTPase: a novel mediator of phosphoinositide signaling

28 September 2017

1 reference

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The neurofibromatosis type 2 gene is mutated in perineurial cell tumors: a molecular genetic study of eight cases.

28 September 2017

1 reference

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Expression of netrin-1 and its receptors DCC and UNC-5H2 after axotomy and during regeneration of adult rat retinal ganglion cells

28 September 2017

1 reference

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Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

28 September 2017

1 reference

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Requirement for Phospholipase C-γ1 Enzymatic Activity in Growth Factor-Induced Mitogenesis

28 September 2017

1 reference

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Intracellular distribution of phospholipase C gamma 1 in cell lines with different levels of transformation

28 September 2017

1 reference

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28 September 2017

1 reference

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Role of proto-oncogene activation in carcinogenesis

28 September 2017

1 reference

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Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-alpha.

28 September 2017

1 reference

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Focal adhesion kinase: at the crossroads of signal transduction.

31 May 2018

1 reference

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Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.

31 May 2018

1 reference

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Activation of receptor-associated tyrosine kinase JAK2 by prolactin

31 May 2018

1 reference

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Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones

31 May 2018

1 reference

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Molecular cloning of a porcine (Sus scrofa) apoptosis inhibitory ligand, netrin-1, and its receptor, p53RDL1.

21 January 2018

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Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types

21 January 2018

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https://api.crossref.org/works/10.1038%2FAPS.2013.71

Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FAPS.2013.71

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.71

Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient src family kinases or p130CAS.

21 January 2018

1 reference

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The LKB1-AMPK pathway-friend or foe in cancer?

21 January 2018

1 reference

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Proto-oncogene products as target antigens for cancer vaccines

21 January 2018

1 reference

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Intranuclear 3'-phosphoinositide metabolism and apoptosis protection in PC12 cells

28 November 2018

1 reference

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Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells

28 November 2018

1 reference

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Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2

28 November 2018

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12 December 2020

Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells

1 reference

12 December 2020

Positional gene expression analysis identifies 12q overexpression and amplification in a subset of neuroblastomas

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12 December 2020

Molecular genotyping of medullary thyroid carcinoma can predict tumor recurrence

1 reference

12 December 2020

Amplification at 12q13-14 in human malignant gliomas is frequently accompanied by loss of heterozygosity at loci proximal and distal to the amplification site

1 reference

12 December 2020

Identifiers

DOI

10.1038/APS.2013.71

1 reference

Dimensions Publication ID

1022702028

0 references

1 reference

1 reference

PubMed publication ID

23770988

1 reference