Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N (Q24290689)

phosphatidylinositol 3-kinase regulator activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

K J Hurt

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Solomon Halbert Snyder

object named as

S H Snyder

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author name string

K Ye

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F Y Wu

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M Fang

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H R Luo

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J J Hong

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S Blackshaw

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C D Ferris

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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language of work or name

English

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publication date

8 December 2000

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published in

Cell

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volume

103

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issue

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page(s)

919-30

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cites work

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7 January 2021

Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells

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The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

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Neurite outgrowth in PC12 cells deficient in GAP-43

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Developmental Expression Pattern of Phototransduction Components in Mammalian Pineal Implies a Light-Sensing Function

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7 January 2021

Intact Ras function is required for sustained activation and nuclear translocation of extracellular signal-regulated kinases in nerve growth factor-stimulated PC12 cells

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Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton

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Oncogenes and signal transduction

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Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis

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7 January 2021

Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling.

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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Biological and biochemical properties of human rasH genes mutated at codon 61.

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Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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Multiple ras effector pathways contribute to G(1) cell cycle progression

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Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

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Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

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Construction of retroviral vectors with improved safety, gene expression, and versatility.

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Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity

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7 January 2021

Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. Use of Cre/loxP recombination system

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Phosphoinositide 3-kinase in rat liver nuclei

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Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell

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Recent insights in phosphatidylinositol signaling

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Phosphatidylinositol 3-Kinase in HL-60 Nuclei Is Bound to the Nuclear Matrix and Increases During Granulocytic Differentiation

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7 January 2021

Nuclear Cotransport Mechanism of Cytoplasmic Human MxB Protein

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Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope

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Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

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Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

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7 January 2021

The basic science of gene therapy

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Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 cells

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7 January 2021

Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

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7 January 2021

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

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7 January 2021

Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly. Properties of purified NuMA protein

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.

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Activation of phosphatidylinositol 3-kinase by insulin

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The small nuclear GTPase Ran: how much does it run?

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Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease

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7 January 2021

The activation and nuclear translocation of extracellular signal-regulated kinases (ERK-1 and -2) appear not to be required for elongation of neurites in PC12D cells

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7 January 2021

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts

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7 January 2021

Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus

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Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase

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Phosphoinositide 3-kinases: A conserved family of signal transducers

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

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NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

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Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor

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