Rational drug design and synthesis of molecules targeting the angiotensin II type 1 and type 2 receptors (Q27023787)

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2 March 2020

review article

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17 July 2021

Rational drug design and synthesis of molecules targeting the angiotensin II type 1 and type 2 receptors (English)

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2 March 2020

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17 July 2021

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2 March 2020

Thomas Mavromoustakos

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2 March 2020

Andreas G Tzakos

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2 March 2020

language of work or name

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2 March 2015

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2 March 2020

17 July 2021

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2 March 2020

17 July 2021

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2 March 2020

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2 March 2020

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3868-3897

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Creative Commons Attribution

2 March 2020

1 reference

17 July 2021

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Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains

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Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

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Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice

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AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression

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Intratracheal administration of a nanoparticle-based therapy with the angiotensin II type 2 receptor gene attenuates lung cancer growth

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Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II.

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The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives

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Angiotensin AT1/AT2 receptors: regulation, signalling and function

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The AT2 receptor--a matter of love and hate

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Radioiodinated CGP 42111A: A novel high affinity and highly selective ligand for the characterization of angiotensin AT2 receptors

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Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.

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Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

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Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice

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The pharmacological effects of novokinin; a designed peptide agonist of the angiotensin AT2 receptor

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Saralasin and Sarile Are AT2 Receptor Agonists

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AT1 antagonists: a patent review (2008 - 2012).

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Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective

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Multitarget Cardiovascular Drugs

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Computational approaches on angiotensin receptors and their ligands: recent developments and results.

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Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers

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International union of pharmacology. XXIII. The angiotensin II receptors

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Multiple templates-based homology modeling enhances structure quality of AT1 receptor: validation by molecular dynamics and antagonist docking

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Comparative study of the AT₁ receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers

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Nonpeptidic angiotensin II AT₁ receptor antagonists derived from 6-substituted aminocarbonyl and acylamino benzimidazoles

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Subclasses of angiotensin II binding sites and their functional significance

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Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists

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The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan

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Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats

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Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres

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Angiotensin receptors

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Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand

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10.3390/MOLECULES20033868

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738535%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

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2 March 2020

PubMed publication ID

2 references

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