Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms (Q26866139)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Rajesh Ramachandra Singh

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

language of work or name

1 reference

1 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

The American Journal of Pathology

16 January 2020

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

180

2 references

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16 January 2020

2 references

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16 January 2020

page(s)

2-11

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors

16 January 2020

cites work

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Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

21 March 2017

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Reduced thymocyte development in sonic hedgehog knockout embryos

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Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

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21 March 2017

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21 March 2017

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 March 2017

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Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes

21 March 2017

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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

21 March 2017

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The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants

21 March 2017

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Identification of a palmitic acid-modified form of human Sonic hedgehog

21 March 2017

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Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

21 March 2017

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 March 2017

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Mutations affecting segment number and polarity in Drosophila

21 March 2017

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Identification of an amplified, highly expressed gene in a human glioma

21 March 2017

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The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms

21 March 2017

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Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism

21 March 2017

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Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

21 March 2017

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Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

21 March 2017

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The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.

21 March 2017

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Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte

21 March 2017

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Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926

21 March 2017

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Sonic hedgehog signaling is essential for hair development

21 March 2017

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Sonic hedgehog is essential to foregut development

21 March 2017

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Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

21 March 2017

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Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

21 March 2017

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Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

21 March 2017

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 March 2017

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7 April 2017

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

7 April 2017

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ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma.

7 April 2017

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Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma

28 September 2017

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Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.

28 September 2017

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Modulators of the hedgehog signaling pathway

28 September 2017

1 reference

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Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.

28 September 2017

1 reference

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Targeting Hedgehog--a cancer stem cell pathway

28 September 2017

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Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.

28 September 2017

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Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals

28 September 2017

1 reference

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Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells

28 September 2017

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

28 September 2017

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Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.

28 September 2017

1 reference

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Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

28 September 2017

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Hedgehog signaling is dispensable for adult hematopoietic stem cell function

28 September 2017

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Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma.

28 September 2017

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Hedgehog signaling: is Smo a G protein-coupled receptor?

28 September 2017

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

28 September 2017

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G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

28 September 2017

1 reference

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A paracrine requirement for hedgehog signalling in cancer

28 September 2017

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Signaling pathways in medulloblastoma

28 September 2017

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Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma

28 September 2017

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Beta-arrestin-mediated localization of smoothened to the primary cilium

28 September 2017

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Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes

28 September 2017

1 reference

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Sonic hedgehog signalling in T-cell development and activation

28 September 2017

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Essential role of stromally induced hedgehog signaling in B-cell malignancies

28 September 2017

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

28 September 2017

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

28 September 2017

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Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer

28 September 2017

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Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos

28 September 2017

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

28 September 2017

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Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

28 September 2017

1 reference

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Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia

28 September 2017

1 reference

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Hedgehog signalling in cancer formation and maintenance

28 September 2017

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Expression of hedgehog proteins in the human thymus

28 September 2017

1 reference

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

28 September 2017

1 reference

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Mutations in SUFU predispose to medulloblastoma

28 September 2017

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Megalin functions as an endocytic sonic hedgehog receptor

28 September 2017

1 reference

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Hedgehog is required for murine yolk sac angiogenesis.

28 September 2017

1 reference

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Translocations involving anaplastic lymphoma kinase (ALK).

28 September 2017

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Development of the hematopoietic system in the mouse.

28 September 2017

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Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.

28 September 2017

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Sertoli cell signaling by Desert hedgehog regulates the male germline

28 September 2017

1 reference

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Molecular analysis of chromosome 9q deletions in two Gorlin syndrome patients

28 September 2017

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Control points in early T-cell development

28 September 2017

1 reference

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Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

28 September 2017

1 reference

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Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

31 May 2018

1 reference

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Dual degradation signals control Gli protein stability and tumor formation

31 May 2018

1 reference

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Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

31 May 2018

1 reference

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Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal

31 May 2018

1 reference

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Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

31 May 2018

1 reference

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Case report: nasopharyngeal rhabdomyosarcoma and Gorlin's naevoid basal cell carcinoma syndrome

31 May 2018

1 reference

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Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

31 May 2018

1 reference

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Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation.

31 May 2018

1 reference

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Interplay between BMP4 and IL-7 in human intrathymic precursor cells.

28 November 2018

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Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells

28 November 2018

1 reference

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Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-beta2m-/- repopulating cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338341

Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells

28 November 2018

1 reference

12 December 2020

Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations

1 reference

12 December 2020

Definitive hematopoiesis is autonomously initiated by the AGM region

1 reference

12 December 2020

Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog

1 reference

12 December 2020

Chromosomal and gene amplification in diffuse large B-cell lymphoma

1 reference

12 December 2020

Sonic Hedgehog Signaling Modulates Activation of and Cytokine Production by Human Peripheral CD4+ T Cells

1 reference

12 December 2020

Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells

1 reference

12 December 2020

10.1016/J.AJPATH.2011.09.009

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

22056910

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056910%20AND%20SRC:MED&resulttype=core&format=json