Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis (Q26852743)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

review article

4 references

5 December 2020

5 July 2021

19 July 2022

Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

main subject

glucose

0 references

physiological phenomenon

1 reference

20 August 2019

1 reference

18 November 2019

1 reference

19 November 2019

1 reference

5 December 2020

1 reference

5 July 2021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

João A B Pedroso

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Thais T Zampieri

series ordinal

1 reference

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15 February 2020

language of work or name

1 reference

22 May 2015

9 references

20 August 2019

18 November 2019

19 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

4 June 2020

5 December 2020

5 July 2021

19 July 2022

8 references

20 August 2019

18 November 2019

19 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

5 December 2020

5 July 2021

19 July 2022

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

page(s)

3914-3937

1 reference

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Creative Commons Attribution

15 February 2020

6 references

20 August 2019

18 November 2019

19 November 2019

5 December 2020

5 July 2021

19 July 2022

0 references

Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice

1 reference

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Interplay between lipids and branched-chain amino acids in development of insulin resistance

7 April 2017

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Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

7 April 2017

1 reference

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

7 April 2017

1 reference

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S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

7 April 2017

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

7 April 2017

1 reference

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Effects of leucine supplemented diet on intestinal absorption in tumor bearing pregnant rats

7 April 2017

1 reference

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Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

7 April 2017

1 reference

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Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes

7 April 2017

1 reference

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Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

An obesity-associated gut microbiome with increased capacity for energy harvest

7 April 2017

1 reference

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Gut hormones and the regulation of energy homeostasis

7 April 2017

1 reference

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Hypothalamic mTOR signaling regulates food intake

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake

7 April 2017

1 reference

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Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Intracellular signalling. Key enzyme in leptin-induced anorexia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Bidirectional transport of amino acids regulates mTOR and autophagy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

A central role for JNK in obesity and insulin resistance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Effects of the obese gene product on body weight regulation in ob/ob mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Neurobiology of food intake in health and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

L-leucine supplementation worsens the adiposity of already obese rats by promoting a hypothalamic pattern of gene expression that favors fat accumulation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine supplementation improves skeletal muscle regeneration after cryolesion in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine supplementation protects from insulin resistance by regulating adiposity levels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

The central nervous system as a promising target to treat diabetes mellitus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

The PI3K signaling pathway mediates the biological effects of leptin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise

28 September 2017

1 reference

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Effects of corn gluten hydrolyzates, branched chain amino acids, and leucine on body weight reduction in obese rats induced by a high fat diet

28 September 2017

1 reference

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Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Long-term effects of leucine supplementation on body composition.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Metabolic and regulatory roles of leucine in neural cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Potential importance of leucine in treatment of obesity and the metabolic syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

The role of leucine in the regulation of protein metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Mechanisms responsible for regulation of branched-chain amino acid catabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

The role of leucine in weight loss diets and glucose homeostasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Bidirectional modulation of insulin action by amino acids

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Hypothalamic eIF2α signaling regulates food intake

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Monosodium Glutamate Administration to the Newborn Reduces Reproductive Ability in Female and Male Mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats

31 May 2018

1 reference

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue

21 January 2018

1 reference

Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system

21 January 2018

1 reference

Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves

21 January 2018

1 reference

Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus).

21 January 2018

1 reference

Effect of a leucine-supplemented diet on body composition changes in pregnant rats bearing Walker 256 tumor

21 January 2018

1 reference

Meal pattern of male rats maintained on histidine-, leucine-, or tyrosine-supplemented diet

21 January 2018

1 reference

Effects of leucine and phenylalanine supplementation during intermittent periods of food restriction and refeeding in adult rats.

21 January 2018

1 reference

Excess leucine intake induces serine dehydratase in rat liver

21 January 2018

1 reference

Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance.

21 January 2018

1 reference

Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing.

21 January 2018

1 reference

Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague-Dawley rats.

21 January 2018

1 reference

Leucine supplementation increases serum insulin-like growth factor 1 concentration and liver protein/RNA ratio in rats after a period of nutritional recovery.

21 January 2018

1 reference

Leucine improves protein nutritional status and regulates hepatic lipid metabolism in calorie-restricted rats.

21 January 2018

1 reference

Effects of whey protein and leucine supplementation on insulin resistance in non-obese insulin-resistant model rats

21 January 2018

1 reference

Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice

21 January 2018

1 reference

Leucing weight with a futile cycle

21 January 2018

1 reference

Leucine is essential for attenuating fetal growth restriction caused by a protein-restricted diet in rats.

21 January 2018

1 reference

Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway.

21 January 2018

1 reference

Leucine supplementation favors liver protein status but does not reduce body fat in rats during 1 week of food restriction.

21 January 2018

1 reference

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

21 January 2018

1 reference

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway

21 January 2018

1 reference

Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men

21 January 2018

1 reference

Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446786

Ingestion of protein hydrolysate and amino acid-carbohydrate mixtures increases postexercise plasma insulin responses in men

28 November 2018

1 reference

12 December 2020

Regulation of branched-chain alpha-ketoacid dehydrogenase kinase

1 reference

12 December 2020

Differential effects of electrolytic and chemical hypothalamic lesions on LH pulses in rats

1 reference

12 December 2020

Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats

1 reference

12 December 2020

Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice

1 reference

12 December 2020

Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction

1 reference

12 December 2020

Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

1 reference

12 December 2020

Effect of chronic supplementation with branched-chain amino acids on the performance and hepatic and muscle glycogen content in trained rats

1 reference

12 December 2020

Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin

1 reference

12 December 2020

Adverse effects of excessive leucine intake depend on dietary protein intake: a transcriptomic analysis to identify useful biomarkers

1 reference

12 December 2020

Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1

1 reference

12 December 2020

Leucine in food mediates some of the postprandial rise in plasma leptin concentrations

1 reference

12 December 2020

Effects of leucine on in vitro protein synthesis and degradation in rat skeletal muscles

1 reference

12 December 2020

Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms

1 reference

12 December 2020

Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal

1 reference

12 December 2020

Leucine supplementation enhances skeletal muscle recovery in rats following exercise

1 reference

12 December 2020

Activation of central orexin/hypocretin neurons by dietary amino acids

1 reference

12 December 2020

Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats

1 reference

12 December 2020

Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats

1 reference

12 December 2020

Identifiers

DOI

10.3390/NU7053914

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

26007339

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26007339%20AND%20SRC:MED&resulttype=core&format=json