On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities (Q26799216)

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English	On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities	scientific article (publication date: 2015)

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instance of

scholarly article

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review article

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Europe PubMed Central

title

On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities (English)

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author

Yufeng Wei

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1

object named as

Yufeng Wei

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language of work or name

English

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publication date

2015

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published in

Pharmaceuticals

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volume

8

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issue

3

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page(s)

455-73

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copyright license

Creative Commons Attribution 4.0 International

start time

31 July 2015

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April 2022 Public Data File from Crossref

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copyrighted

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cites work

PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells

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The PEA-15 protein regulates autophagy via activation of JNK

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Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia

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7 April 2017

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

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7 April 2017

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

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7 April 2017

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

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7 April 2017

Electrostatics of nanosystems: application to microtubules and the ribosome

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7 April 2017

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

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PubMed Central

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7 April 2017

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

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PubMed Central

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7 April 2017

The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human

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PubMed Central

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7 April 2017

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

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PubMed Central

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7 April 2017

High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions

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PubMed Central

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7 April 2017

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain

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PubMed Central

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7 April 2017

RSK2 activity is regulated by its interaction with PEA-15

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PubMed Central

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7 April 2017

The Ras-Raf-MEK-ERK pathway in the treatment of cancer

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PubMed Central

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7 April 2017

Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells

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PubMed Central

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7 April 2017

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

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PubMed Central

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7 April 2017

Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them

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PubMed Central

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7 April 2017

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

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PubMed Central

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7 April 2017

Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics

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PubMed Central

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7 April 2017

Death effector domain-containing proteins

1 reference

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PubMed Central

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7 April 2017

Cell death in the nervous system

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PubMed Central

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7 April 2017

PTEN regulatory functions in tumor suppression and cell biology

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PubMed Central

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7 April 2017

Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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7 April 2017

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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PubMed Central

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7 April 2017

Characterization of PEA-15, a major substrate for protein kinase C in astrocytes

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PubMed Central

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7 April 2017

Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats

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7 April 2017

The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity

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PubMed Central

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7 April 2017

Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei

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PubMed Central

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28 September 2017

Development of PEA-15 using a potent non-viral vector for therapeutic application in breast cancer

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PubMed Central

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28 September 2017

Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Substantial conformational change mediated by charge-triad residues of the death effector domain in protein-protein interactions

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PubMed Central

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28 September 2017

PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

The PEA-15/PED protein regulates cellular survival and invasiveness in colorectal carcinomas

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway

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PubMed Central

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28 September 2017

Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models.

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PubMed Central

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28 September 2017

Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter

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PubMed Central

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28 September 2017

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

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28 September 2017

Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch

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PubMed Central

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28 September 2017

MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model

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PubMed Central

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28 September 2017

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Activated ERK2 Is a Monomer in Vitro with or without Divalent Cations and When Complexed to the Cytoplasmic Scaffold PEA-15

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Residues 762-801 of PLD1 mediate the interaction with PED/PEA15.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

PED/PEA-15 modulates coxsackievirus-adenovirus receptor expression and adenoviral infectivity via ERK-mediated signals in glioma cells.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

AMPK in Health and Disease

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

The death domain superfamily in intracellular signaling of apoptosis and inflammation

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

PED mediates AKT-dependent chemoresistance in human breast cancer cells

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Protein phosphatase 4--from obscurity to vital functions

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

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28 September 2017

Control of MAP kinase signaling to the nucleus.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Regulation of sensitivity to TRAIL by the PTEN tumor suppressor.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 September 2017

PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

31 May 2018

PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

31 May 2018

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15).

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

Expression of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) in astrocytic tumors: a novel approach of correlating malignancy grade and prognosis

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pat

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

Identification of proteins regulated by estradiol in focal cerebral ischemic injury--a proteomics approach

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.3390%2FPH8030455

retrieved

21 January 2018

PEP-1-PEA-15 protects against toxin-induced neuronal damage in a mouse model of Parkinson's disease

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 November 2018

Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 November 2018

Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588177

retrieved

28 November 2018

Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26263999

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of Metastatic Potential of Murine and Human Melanoma Cells by Laminin Receptor Peptide G: Attachment of Cancer Cells to Subendothelial Matrix as a Pathway for Hematogenous Metastasis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26263999

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of FADD and its mode of interaction with procaspase-8

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26263999

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.3390/PH8030455

0 references

PMC publication ID

4588177

0 references

PubMed publication ID

26263999

0 references

ResearchGate publication ID

280998619

0 references

 

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