Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action (Q24683017)

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Angela Cassese

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Giovanni Vigliotta

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Claudia Miele

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Francesco Oriente

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Stefania Santopietro

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Ferdinando Giacco

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Gerolama Condorelli

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Pietro Formisano

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Francesco Beguinot

Molecular and Cellular Biology

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language of work or name

English

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publication date

July 2003

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published in

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volume

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issue

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page(s)

4511-21

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cites work

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

7 April 2017

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PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

7 April 2017

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Bcl-2 targets the protein kinase Raf-1 to mitochondria

7 April 2017

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Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain

7 April 2017

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

7 April 2017

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Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA

7 April 2017

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Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells

7 April 2017

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Identification of 14-3-3zeta as a protein kinase B/Akt substrate

7 April 2017

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Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

7 April 2017

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PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

7 April 2017

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Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

7 April 2017

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CREB is a regulatory target for the protein kinase Akt/PKB

7 April 2017

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Regulation of cell death protease caspase-9 by phosphorylation

7 April 2017

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Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro

7 April 2017

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Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers

7 April 2017

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

7 April 2017

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Characterization of PEA-15, a major substrate for protein kinase C in astrocytes

7 April 2017

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The protein kinase B/Akt signalling pathway in human malignancy

7 April 2017

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 April 2017

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

7 April 2017

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

7 April 2017

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

7 April 2017

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AKT plays a central role in tumorigenesis

28 September 2017

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Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line

28 September 2017

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14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase

28 September 2017

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

28 September 2017

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Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation

30 May 2018

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Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.

28 November 2018

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

28 November 2018

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Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate.

28 November 2018

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