Cancer stem cell targeted therapy: progress amid controversies. (Q26779931)

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Cancer stem cell targeted therapy: progress amid controversies (English)

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neoplastic stem cells

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1 reference

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Tao Wang

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Sarah Shigdar

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Li Wang

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Yong Li

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Wang Yin

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Shu-Feng Zhou

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Xinhan Zhao

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1 December 2015

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29 December 2015

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8 February 2021

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3 April 2019

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25 June 2019

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12 October 2019

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44191-44206

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Creative Commons Attribution 2.5 Generic

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Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

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Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

7 April 2017

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

7 April 2017

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7 April 2017

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28 September 2017

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Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer

28 September 2017

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Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways

28 September 2017

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Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration

28 September 2017

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Chromatin repressive complexes in stem cells, development, and cancer

28 September 2017

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28 September 2017

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Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells

28 September 2017

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Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)

28 September 2017

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Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways

28 September 2017

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Metastatic stem cells: sources, niches, and vital pathways

28 September 2017

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Evolution of the cancer stem cell model

28 September 2017

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Lack of correlation of stem cell markers in breast cancer stem cells.

28 September 2017

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Activated leukocyte cell adhesion molecule (CD166): an "inert" cancer stem cell marker for non-small cell lung cancer?

28 September 2017

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Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective

28 September 2017

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Cancer stem cells, a fuzzy evolving concept: a cell population or a cell property?

28 September 2017

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Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin

28 September 2017

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TRAIL on trial: preclinical advances in cancer therapy

28 September 2017

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A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells

28 September 2017

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Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.

28 September 2017

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Evaluating cell lines as tumour models by comparison of genomic profiles

28 September 2017

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HER2 and breast cancer stem cells: more than meets the eye.

28 September 2017

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Understanding and targeting cancer stem cells: therapeutic implications and challenges

28 September 2017

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Efficacy of using cancer stem cell markers in isolating and characterizing liver cancer stem cells.

28 September 2017

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Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma

28 September 2017

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Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

28 September 2017

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Growth factor receptors define cancer hierarchies

28 September 2017

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Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models

28 September 2017

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Therapeutic strategies targeting cancer stem cells

28 September 2017

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Wnt signaling in stem and cancer stem cells

28 September 2017

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Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

28 September 2017

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ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL.

28 September 2017

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Intravital imaging of cancer stem cell plasticity in mammary tumors

28 September 2017

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RNA aptamers targeting cancer stem cell marker CD133.

28 September 2017

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The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment

28 September 2017

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Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization

28 September 2017

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A review on CXCR4/CXCL12 axis in oncology: no place to hide.

28 September 2017

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A detailed mammosphere assay protocol for the quantification of breast stem cell activity.

28 September 2017

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Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

28 September 2017

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Tracing epithelial stem cells during development, homeostasis, and repair

28 September 2017

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Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

28 September 2017

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Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

28 September 2017

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Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

28 September 2017

1 reference

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Humanized Rag1−/−γc−/− Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes

28 September 2017

1 reference

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Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells

28 September 2017

1 reference

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The cancer stem cell: premises, promises and challenges

28 September 2017

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Phenotypic Heterogeneity of Breast Cancer Stem Cells

28 September 2017

1 reference

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Targeting apoptosis pathways in cancer stem cells

28 September 2017

1 reference

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Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

28 September 2017

1 reference

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Acidic stress promotes a glioma stem cell phenotype.

28 September 2017

1 reference

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Mobilization of hematopoietic stem cells into the peripheral blood

28 September 2017

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Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Brain tumor stem cells: The cancer stem cell hypothesis writ large

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

More than markers: biological significance of cancer stem cell-defining molecules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Targeting Hedgehog--a cancer stem cell pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Targeting Notch to target cancer stem cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

The cancer stem cell paradigm: a new understanding of tumor development and treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Plerixafor: a peripheral blood stem cell mobilizer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Cytoplasmic accumulation of connexin32 expands cancer stem cell population in human HuH7 hepatoma cells by enhancing its self-renewal.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Neoplastic stem cells: current concepts and clinical perspectives.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

CD44+ cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast tumours

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Cancer stem cell and cancer stemloids: from biology to therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

"Destemming" cancer stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Targeted therapy for cancer stem cells: the patched pathway and ABC transporters

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Target for cancer therapy: proliferating cells or stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Stem cell plasticity: the growing potential of cellular therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Fibroblast-derived CCL2 induces cancer stem cells--response

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Timeline: Chemotherapy and the war on cancer.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

A model of human acute lymphoblastic leukemia in immune-deficient SCID mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

The cancer stem cell gamble.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Cancer stem cells: moving past the controversy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

What makes cancer stem cell markers different?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Cancer stem cell definitions and terminology: the devil is in the details.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Orthotopic glioblastoma stem-like cell xenograft model in mice to evaluate intra-arterial delivery of bevacizumab: from bedside to bench

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

aSIRTing control over cancer stem cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

ABC transporters in cancer: more than just drug efflux pumps.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Comment on "Tumor growth need not be driven by rare cancer stem cells".

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792551

Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

28 November 2018

1 reference

12 December 2020

Tumor growth need not be driven by rare cancer stem cells

1 reference

12 December 2020

Melanoma in mice casts doubt on scarcity of cancer stem cells

1 reference

12 December 2020

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

1 reference

12 December 2020

CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

1 reference

12 December 2020

Cancer stem cells: an evolving concept

1 reference

12 December 2020

Nitrogen mustard therapy in the reticuloses

1 reference

12 December 2020

Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation

1 reference

12 December 2020

Cancer stem cells: the challenges ahead

1 reference

12 December 2020

Plasticity of marrow-derived stem cells

1 reference

12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.6176

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496035%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

28 February 2020

407263

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

407263

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496035%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

26496035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496035%20AND%20SRC:MED&resulttype=core&format=json