Common mechanisms of PIKK regulation (Q24653672)

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Language	Label	Description	Also known as
English	Common mechanisms of PIKK regulation	scientific article

Statements

instance of

scholarly article

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review article

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stated in

Europe PubMed Central

title

Common mechanisms of PIKK regulation (English)

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main subject

cell biology

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author name string

Courtney A Lovejoy

series ordinal

1

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David Cortez

series ordinal

2

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language of work or name

English

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publication date

2 September 2009

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published in

DNA Repair

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volume

8

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issue

9

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page(s)

1004-8

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cites work

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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PubMed Central

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7 April 2017

ATMIN defines an NBS1-independent pathway of ATM signalling

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7 April 2017

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

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PubMed Central

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7 April 2017

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

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PubMed Central

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7 April 2017

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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PubMed Central

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7 April 2017

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

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PubMed Central

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7 April 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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PubMed Central

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7 April 2017

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

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PubMed Central

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7 April 2017

Replication protein A-mediated recruitment and activation of Rad17 complexes

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PubMed Central

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7 April 2017

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

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PubMed Central

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7 April 2017

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

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PubMed Central

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7 April 2017

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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PubMed Central

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7 April 2017

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

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PubMed Central

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7 April 2017

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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PubMed Central

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7 April 2017

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

Rheb binds and regulates the mTOR kinase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

ATR and ATRIP: partners in checkpoint signaling

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

The DNA-dependent protein kinase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

ATR: an essential regulator of genome integrity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

A dynamic model for replication protein A (RPA) function in DNA processing pathways

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

TopBP1 activates the ATR-ATRIP complex

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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7 April 2017

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Activation of ATR and related PIKKs

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Activation of the cellular DNA damage response in the absence of DNA lesions

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

ATR signaling can drive cells into senescence in the absence of DNA breaks

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Rapid activation of ATM on DNA flanking double-strand breaks

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

The structural determinants of checkpoint activation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Function of a conserved checkpoint recruitment domain in ATRIP proteins

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Involvement of novel autophosphorylation sites in ATM activation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Identification and functional analysis of TopBP1 and its homologs

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

The Mre11 complex is required for ATM activation and the G2/M checkpoint

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Requirement of the MRN complex for ATM activation by DNA damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

A Role for the Phosphorylation of hRad9 in Checkpoint Signaling

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 September 2017

Aven-dependent activation of ATM following DNA damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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30 May 2018

ATRIP oligomerization is required for ATR-dependent checkpoint signaling

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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30 May 2018

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 November 2018

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 November 2018

The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725225

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28 November 2018

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19464237

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19464237

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19464237

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FAT: a novel domain in PIK-related kinases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19464237

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.DNAREP.2009.04.006

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1230210

OpenCitations bibliographic resource ID

1230210

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1230210

PMC publication ID

2725225

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1230210

PubMed publication ID

19464237

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1230210

 

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