Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1 (Q24655984)

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Warner B Bair

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Alexandra S Bause

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Georg T Wondrak

The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth

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language of work or name

English

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publication date

15 August 2009

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published in

Biochemical Pharmacology

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volume

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issue

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page(s)

344-54

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cites work

1 reference

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The in vivo gene expression signature of oxidative stress

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Experimental therapeutics: targeting the redox Achilles heel of cancer

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Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells

7 April 2017

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NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics

7 April 2017

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Ascorbate in plasma as measured by liquid chromatography and by dichlorophenolindophenol colorimetry

7 April 2017

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NAD(P)H:quinone oxidoreductase (NQO1) loss of function in Burkitt's lymphoma cell lines

7 April 2017

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Reactive oxygen species: an Achilles' heel of melanoma?

28 September 2017

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Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside

28 September 2017

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Biochemical mechanism of acetaminophen (APAP) induced toxicity in melanoma cell lines

28 September 2017

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Elesclomol induces cancer cell apoptosis through oxidative stress

28 September 2017

1 reference

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Platinums sensitize human epithelial tumor cells to lymphotoxin alpha by inhibiting NFkappaB-dependent transcription

28 September 2017

1 reference

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Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives

28 September 2017

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Apoptosis/necrosis switch in two different cancer cell lines: influence of benzoquinone- and hydrogen peroxide-induced oxidative stress intensity, and glutathione

28 September 2017

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The reactive oxygen-driven tumor: relevance to melanoma

28 September 2017

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Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells

28 September 2017

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Reactive oxygen species in melanoma and its therapeutic implications

28 September 2017

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Induction of heat shock proteins in differentiated human and rodent neurons by celastrol

28 September 2017

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NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosis

28 September 2017

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Reactive oxygen species: a breath of life or death?

28 September 2017

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Dimethylfumarate impairs melanoma growth and metastasis

28 September 2017

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Motexafin gadolinium: a novel redox active drug for cancer therapy

28 September 2017

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Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

28 September 2017

1 reference

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Artesunate in the treatment of metastatic uveal melanoma--first experiences

28 September 2017

1 reference

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Antimelanoma activity of apoptogenic carbonyl scavengers

28 September 2017

1 reference

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The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin.

28 September 2017

1 reference

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Multifunctional redox catalysts as selective enhancers of oxidative stress

28 September 2017

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Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy.

28 September 2017

1 reference

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Controlling tumor growth by modulating endogenous production of reactive oxygen species.

28 September 2017

1 reference

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Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Curcumin-induced GADD153 gene up-regulation in human colon cancer cells

28 September 2017

1 reference

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DT-diaphorase: a target for new anticancer drugs

28 September 2017

1 reference

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Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity

28 September 2017

1 reference

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mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

28 September 2017

1 reference

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An NAD(P)H oxidase regulates growth and transcription in melanoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Human tumor models in the severe combined immune deficient ( scid ) mouse

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Nonenzymatic NADPH-dependent reduction of 2,6-dichlorophenol-indophenol

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Determination of oxidation-reduction potentials.

30 May 2018

1 reference

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NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Hsp70B' and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Reactive oxygen species may have antitumor activity in metastatic melanoma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Discriminating redox cycling and arylation pathways of reactive chemical toxicity in trout hepatocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742658

The putative benzene metabolite 2,3, 5-tris(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells

28 November 2018

1 reference

12 December 2020

In silico identification and biochemical characterization of novel inhibitors of NQO1

1 reference

12 December 2020

Conjugation of 2,6-Dichloroindophenol with Mitochondrial Thiol Groups

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12 December 2020

Photoreduction and Photophosphorylation with Tris-Washed Chloroplasts

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12 December 2020

Investigation by amperometric methods of intracellular reduction of 2,6-dichlorophenolindophenol in normal and transformed hepatocytes in the presence of different inhibitors of cellular metabolism

1 reference

12 December 2020

2,6-Dichloro-phenol indophenol prevents switch-over of electrons between the cyanide-sensitive and -insensitive pathway of the mitochondrial electron transport chain in the presence of inhibitors

1 reference

12 December 2020