GRK2: multiple roles beyond G protein-coupled receptor desensitization (Q24624571)

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English	GRK2: multiple roles beyond G protein-coupled receptor desensitization	scientific article

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instance of

scholarly article

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title

GRK2: multiple roles beyond G protein-coupled receptor desensitization (English)

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main subject

G protein-coupled receptor

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desensitization

1 reference

based on heuristic

inferred from title

author

Marc Caron

series ordinal

3

object named as

Marc G Caron

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author name string

Tama Evron

series ordinal

1

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Tanya L Daigle

series ordinal

2

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language of work or name

English

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publication date

March 2012

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published in

Trends in Pharmacological Sciences

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volume

33

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issue

3

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page(s)

154-64

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cites work

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G protein-coupled receptor kinase 2 positively regulates epithelial cell migration

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beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

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Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus

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Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

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The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling

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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

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7 April 2017

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

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Identification of G protein-coupled receptor genes from the human genome sequence

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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Regulation of G protein-coupled receptor kinases by caveolin

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7 April 2017

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

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7 April 2017

Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3

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7 April 2017

Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration

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7 April 2017

Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control

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7 April 2017

Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2

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7 April 2017

Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

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7 April 2017

The primary cilium: a signalling centre during vertebrate development

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7 April 2017

Seven-transmembrane receptors

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7 April 2017

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

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7 April 2017

GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.

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27 September 2017

Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane

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27 September 2017

Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases

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27 September 2017

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.

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27 September 2017

β-Arrestin-mediated receptor trafficking and signal transduction

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27 September 2017

Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling

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27 September 2017

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

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27 September 2017

Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.

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27 September 2017

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.

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27 September 2017

Vertebrate Hedgehog signaling: cilia rule

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27 September 2017

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity

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27 September 2017

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

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27 September 2017

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish.

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27 September 2017

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain

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27 September 2017

G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression

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27 September 2017

G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells.

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27 September 2017

G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation

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27 September 2017

G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

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27 September 2017

Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development

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27 September 2017

New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration

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27 September 2017

G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.

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27 September 2017

Hedgehog signaling: is Smo a G protein-coupled receptor?

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27 September 2017

Molecular and cellular biology of synucleins

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27 September 2017

The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear.

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27 September 2017

Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase

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27 September 2017

Beta-arrestin-mediated localization of smoothened to the primary cilium

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27 September 2017

Immunohistochemical detection, regulation and antiproliferative function of G-protein-coupled receptor kinase 2 in thyroid carcinomas

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27 September 2017

Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment

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27 September 2017

Phosphorylation-independent attenuation of GPCR signalling

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27 September 2017

Physiological roles of G protein-coupled receptor kinases and arrestins

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27 September 2017

Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.

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27 September 2017

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2

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27 September 2017

Activation of heterotrimeric G proteins by Smoothened

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27 September 2017

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

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27 September 2017

A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

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27 September 2017

The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction

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27 September 2017

G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton

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27 September 2017

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling

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27 September 2017

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor

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27 September 2017

GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation

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PubMed Central

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27 September 2017

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

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27 September 2017

Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo

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27 September 2017

Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin

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27 September 2017

Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex

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27 September 2017

Clathrin box in G protein-coupled receptor kinase 2.

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PubMed Central

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27 September 2017

Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration

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27 September 2017

The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin

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27 September 2017

Beta-adrenergic receptor kinase (GRK2) colocalizes with beta-adrenergic receptors during agonist-induced receptor internalization

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27 September 2017

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

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27 September 2017

Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases

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27 September 2017

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization

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Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

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30 May 2018

Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.

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30 May 2018

Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons

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30 May 2018

G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits

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30 May 2018

G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes

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Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq

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30 May 2018

TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration

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28 November 2018

FMRP acts as a key messenger for dopamine modulation in the forebrain

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28 November 2018

Taxol normalizes the impaired agonist-induced beta2-adrenoceptor internalization in splenocytes from GRK2+/- mice.

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28 November 2018

Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.

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28 November 2018

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex

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28 November 2018

Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex

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28 November 2018

L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain

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28 November 2018

Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway

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28 November 2018

Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors

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28 November 2018

GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin

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28 November 2018

Binding and phosphorylation of tubulin by G protein-coupled receptor kinases

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28 November 2018

G protein-coupled receptor kinases

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors

1 reference

stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/22277298

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22277298

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.TIPS.2011.12.003

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1817902

OpenCitations bibliographic resource ID

1817902

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1817902

PMC publication ID

3294176

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1817902

PubMed publication ID

22277298

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1817902

ResearchGate publication ID

221777420

0 references

 

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