Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. (Q39652655)

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14 February 2020

title

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK (English)

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14 February 2020

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14 February 2020

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14 February 2020

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14 February 2020

Huijing Wang

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14 February 2020

Anibal Garza-Carbajal

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14 February 2020

Hanneke L D M Willemen

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14 February 2020

Fried J Zwartkruis

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14 February 2020

John N Wood

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14 February 2020

Cobi J Heijnen

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14 February 2020

Annemieke Kavelaars

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14 February 2020

language of work or name

English

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publication date

1 September 2010

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14 February 2020

published in

Journal of Neuroscience

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14 February 2020

volume

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issue

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14 February 2020

page(s)

12806-12815

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describes a project that uses

14 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

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Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia

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Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid.

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Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons

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Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice

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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

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Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4

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Rap1 regulates E-cadherin-mediated cell-cell adhesion

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Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice

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G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis

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Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

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12 December 2020

G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton

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12 December 2020

Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

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G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits

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Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain

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Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.

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Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.

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Epac proteins: multi-purpose cAMP targets

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G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice.

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Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

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A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats

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IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

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Rap1 is involved in the signal transduction of myelin-associated glycoprotein

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Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus

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Application of an Epac activator enhances neurotransmitter release at excitatory central synapses.

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Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization

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12 December 2020

Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

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12 December 2020

Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons

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12 December 2020

Activation of Gi induces mechanical hyperalgesia poststress or inflammation

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12 December 2020

PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons

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12 December 2020

Critical role of nociceptor plasticity in chronic pain

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12 December 2020

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain

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Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

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In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs

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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

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Rapid Ca2+-mediated activation of Rap1 in human platelets

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The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin

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Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization

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12 December 2020

GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin

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12 December 2020

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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12 December 2020

10.1523/JNEUROSCI.3142-10.2010

Identifiers

DOI

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14 February 2020

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14 February 2020

PubMed publication ID

20861385

1 reference

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