Mammalian target of rapamycin: a central node of complex signaling cascades (Q24601702)

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English	Mammalian target of rapamycin: a central node of complex signaling cascades	scientific article

Statements

instance of

scholarly article

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review article

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stated in

Europe PubMed Central

title

Mammalian target of rapamycin: a central node of complex signaling cascades (English)

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main subject

sirolimus

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based on heuristic

inferred from title

author name string

Yoh Dobashi

series ordinal

1

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Yasutaka Watanabe

series ordinal

2

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Chihiro Miwa

series ordinal

3

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Sakae Suzuki

series ordinal

4

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Shinichiro Koyama

series ordinal

5

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language of work or name

English

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publication date

20 June 2011

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published in

International Journal of Clinical and Experimental Pathology

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volume

4

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issue

5

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page(s)

476-95

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cites work

Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony

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Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy

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7 April 2017

Overcoming cisplatin resistance by mTOR inhibitor in lung cancer

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7 April 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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7 April 2017

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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7 April 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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7 April 2017

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

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7 April 2017

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

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7 April 2017

Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells

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7 April 2017

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation

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7 April 2017

Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae

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7 April 2017

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

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7 April 2017

Phosphorylation and activation of p70s6k by PDK1

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7 April 2017

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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7 April 2017

TOR signaling in growth and metabolism

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7 April 2017

TSC2 mediates cellular energy response to control cell growth and survival

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7 April 2017

The phosphoinositide 3-kinase pathway

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7 April 2017

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

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7 April 2017

TOR, a central controller of cell growth

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7 April 2017

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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7 April 2017

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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7 April 2017

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

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7 April 2017

mTOR and cancer therapy

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7 April 2017

An expanding role for mTOR in cancer

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7 April 2017

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

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7 April 2017

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

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PubMed Central

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7 April 2017

Rheb binds and regulates the mTOR kinase

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7 April 2017

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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7 April 2017

Upstream and downstream of mTOR

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7 April 2017

Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin

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7 April 2017

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

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7 April 2017

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

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PubMed Central

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7 April 2017

Global and gene-specific translational regulation in rat lung development

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7 April 2017

Role of mTOR signaling in intestinal cell migration

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7 April 2017

Targeting cancer with small molecule kinase inhibitors

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7 April 2017

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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7 April 2017

Ras, PI(3)K and mTOR signalling controls tumour cell growth

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7 April 2017

Growing roles for the mTOR pathway

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7 April 2017

ERBB receptors and cancer: the complexity of targeted inhibitors

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7 April 2017

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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7 April 2017

The TOR pathway: a target for cancer therapy

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7 April 2017

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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7 April 2017

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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7 April 2017

Regulation of translation initiation by FRAP/mTOR

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7 April 2017

Everolimus for advanced pancreatic neuroendocrine tumors.

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27 September 2017

Mammalian target of rapamycin regulates expression of β-catenin in hepatocellular carcinoma

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27 September 2017

Kinase-driven pathways of EGFR in lung carcinomas: perspectives on targeting therapy

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27 September 2017

A comprehensive map of the mTOR signaling network

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27 September 2017

The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma

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27 September 2017

Decreased level of PDCD4 (programmed cell death 4) protein activated cell proliferation in the lung of A/J mouse

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27 September 2017

mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes

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27 September 2017

Advances in target therapy for lung cancer

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27 September 2017

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

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27 September 2017

EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors

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27 September 2017

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

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27 September 2017

Everolimus restores gefitinib sensitivity in resistant non-small cell lung cancer cell lines

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27 September 2017

Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung

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27 September 2017

mTOR signaling contributes to chondrocyte differentiation

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27 September 2017

All roads lead to mTOR: integrating inflammation and tumor angiogenesis

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27 September 2017

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.

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27 September 2017

The biology behind mTOR inhibition in sarcoma

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27 September 2017

Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells

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27 September 2017

mTOR, translation initiation and cancer

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27 September 2017

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

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27 September 2017

Hypoxia signalling in cancer and approaches to enforce tumour regression

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27 September 2017

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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27 September 2017

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

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27 September 2017

Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling

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27 September 2017

mTOR signaling: implications for cancer and anticancer therapy

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27 September 2017

The mammalian target of the rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy.

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27 September 2017

mTOR, a new therapeutic target in acute myeloid leukemia

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PubMed Central

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27 September 2017

The Akt-mTOR tango and its relevance to cancer

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27 September 2017

mTOR--beyond transplantation

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27 September 2017

Autophagy in metazoans: cell survival in the land of plenty

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27 September 2017

Drug eluting stents in 2005.

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27 September 2017

mTOR-targeted therapy of cancer with rapamycin derivatives

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27 September 2017

Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.

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27 September 2017

Targeting the molecular target of rapamycin (mTOR).

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27 September 2017

Dysregulation of the TSC-mTOR pathway in human disease

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

eIF4E--from translation to transformation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

mTOR-mediated regulation of translation factors by amino acids

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Tor signalling in bugs, brain and brawn

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Clinical development of mammalian target of rapamycin inhibitors

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

27 September 2017

The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

30 May 2018

Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Prognostic role of p-mTOR expression in cancer tissues and metastatic lymph nodes in pT2b gastric cancer

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Critical and diverse involvement of Akt/mammalian target of rapamycin signaling in human lung carcinomas

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Profiling of protein kinases in the neoplastic transformation of human ovarian surface epithelium.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127069

retrieved

28 November 2018

Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21738819

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21738819

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The eukaryotic initiation factor 4E-binding proteins and apoptosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21738819

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of survivin expression by IGF-1/mTOR signaling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21738819

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21738819

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

PMC publication ID

3127069

0 references

PubMed publication ID

21738819

0 references

 

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