Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. (Q24537419)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11159437%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis (English)

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3 November 2019

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3 November 2019

J L Penzotti

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3 November 2019

G Lipkind

series ordinal

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3 November 2019

H A Fozzard

series ordinal

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3 November 2019

language of work or name

English

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publication date

1 February 2001

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3 November 2019

number of pages

1 reference

based on heuristic

inferred from page(s)

published in

Biophysical Journal

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3 November 2019

volume

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3 November 2019

issue

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3 November 2019

page(s)

698-706

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Interactions of neosaxitoxin with the sodium channel of the frog skeletal muscle fiber

3 November 2019

cites work

1 reference

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24 March 2017

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The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

24 March 2017

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Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.

24 March 2017

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On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving

27 September 2017

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Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis

27 September 2017

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On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

27 September 2017

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A large photolysis-induced pKa increase of the chromophore counterion in bacteriorhodopsin: implications for ion transport mechanisms of retinal proteins

27 September 2017

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Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

27 September 2017

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Specificity for block by saxitoxin and divalent cations at a residue which determines sensitivity of sodium channel subtypes to guanidinium toxins

27 September 2017

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A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

27 September 2017

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Environmental effects on the protonation states of active site residues in bacteriorhodopsin

27 September 2017

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Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels

27 September 2017

1 reference

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Abnormally high pKa of an active-site glutamic acid residue in Bacillus circulans xylanase. The role of electrostatic interactions

27 September 2017

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Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins

27 September 2017

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Ionic Blockage of Sodium Channels in Nerve

27 September 2017

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Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle

27 September 2017

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The receptor for tetrodotoxin and saxitoxin. A structural hypothesis

27 September 2017

1 reference

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Aspartate substitutions establish the concerted action of P-region glutamates in repeats I and III in forming the protonation site of L-type Ca2+ channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301268

Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve

30 May 2018

1 reference

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Chemistry and biochemistry of saxitoxin analogues and tetrodotoxin.

30 May 2018

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A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

30 May 2018

1 reference

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Effects of external protons on single cardiac sodium channels from guinea pig ventricular myocytes

30 May 2018

1 reference

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Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301268

Actions of decarbamoyloxysaxitoxin and decarbamoylneosaxitoxin on the frog skeletal muscle fiber

30 May 2018

1 reference

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The conserved, buried aspartic acid in oxidized Escherichia coli thioredoxin has a pKa of 7.5. Its titration produces a related shift in global stability

30 May 2018

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Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis

19 June 2018

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Site-directed mutagenesis of the putative pore region of the rat IIA sodium channel.

29 November 2018

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Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles

29 November 2018

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Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

29 November 2018

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pKa of the protonated Schiff base and aspartic 85 in the bacteriorhodopsin binding site is controlled by a specific geometry between the two residues.

29 November 2018

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The active guanidinium group of saxitoxin and neosaxitoxin identified by the effects of pH on their activities on squid axon.

29 November 2018

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Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon

29 November 2018

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Structure-activity relations of tetrodotoxin, saxitoxin, and analogues.

29 November 2018

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Cysteine mapping in the ion selectivity and toxin binding region of the cardiac Na+ channel pore

29 November 2018

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Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis

7 January 2021

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Aromatic rings act as hydrogen bond acceptors

7 January 2021

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7 January 2021

Structure of saxitoxin

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Presence of four toxins in red tide infested clams and cultured Gonyaulax tamarensis cells

7 January 2021

1 reference

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10.1016/S0006-3495(01)76049-3

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11159437%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11159437%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

11159437

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11159437%20AND%20SRC:MED&resulttype=core&format=json