Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease (Q24323316)

3',5'-cyclic-GMP phosphodiesterase activity

GOA release 2020-03-11

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GOA release 2020-03-11

Phosphodiesterase 9A

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GOA release 2020-03-11

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Peter P Rainer

Peter P

Rainer

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7 June 2020

Jonathan A Kirk

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Dong I Lee

Dong I

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Guangshuo Zhu

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Takashi Sasaki

Takashi

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Gun-Sik Cho

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Nazha Hamdani

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Ronald Holewinski

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Thomas Danner

Thomas

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Manling Zhang

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Djahida Bedja

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Mark J Ranek

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Wolfgang R Dostmann

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Kenneth B Margulies

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Jennifer E Van Eyk

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Walter J Paulus

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Eiki Takimoto

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language of work or name

English

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publication date

26 March 2015

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published in

Nature

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7 June 2020

volume

519

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issue

7544

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page(s)

472-476

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25799991%20AND%20SRC:MED&resulttype=core&format=json

Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase

7 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Nitric oxide synthases in heart failure

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Angiotensin-neprilysin inhibition versus enalapril in heart failure

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer's disease: a translational overview.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Advances in targeting cyclic nucleotide phosphodiesterases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Designer natriuretic peptides: a vision for the future of heart failure therapeutics

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Role of cyclic GMP in gene regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

In vivo reconstitution of the negative feedback in nitric oxide/cGMP signaling: role of phosphodiesterase type 5 phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376609

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

27 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14332

Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14332

Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14332

Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14332

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14332

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14332

Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14332

21 January 2018

Identifiers

DOI

10.1038/NATURE14332

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25799991%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

1000839979

0 references

Fatcat ID

release_xg6tdbzxr5horgatwsc6ei5wdi

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25799991%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

25799991

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25799991%20AND%20SRC:MED&resulttype=core&format=json