Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive (Q34287061)
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| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive |
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Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive (English)
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Robin J Kleiman
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Patrick R Verhoest
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Kari R Fonseca
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Xinjun Hou
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Caroline Proulx-Lafrance
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Michael Corman
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Christopher J Helal
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Michelle M Claffey
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Jamison B Tuttle
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Karen J Coffman
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Shenpinq Liu
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Frederick Nelson
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Frank S Menniti
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Christopher J Schmidt
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Michelle Vanase-Frawley
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Spiros Liras
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25 July 2012
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55
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21
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9045-9054
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Identifiers
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