The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins (Q24321847)

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20 January 2020

title

The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16643902%20AND%20SRC:MED&resulttype=core&format=json

Suppressor of cytokine signaling 6

20 January 2020

main subject

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GOA release 2020-03-11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16643902%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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20 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16643902%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Julie Bayle

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16643902%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Sophie Lopez

series ordinal

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20 January 2020

language of work or name

English

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publication date

21 April 2006

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20 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16643902%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

580

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20 January 2020

issue

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20 January 2020

page(s)

2609-2614

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The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

20 January 2020

cites work

1 reference

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Negative regulation of cytokine and TLR signalings by SOCS and others

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Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

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Gigantism in mice lacking suppressor of cytokine signalling-2

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SOCS-3 is an insulin-induced negative regulator of insulin signaling

21 January 2018

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Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

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Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

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Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

21 January 2018

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Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling

21 January 2018

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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

21 January 2018

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Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

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Cloning and characterization of novel CIS family genes

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

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The SOCS box: a tale of destruction and degradation

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

21 January 2018

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

21 January 2018

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Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

21 January 2018

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Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

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The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein

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Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins

21 January 2018

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A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4

21 January 2018

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.

21 January 2018

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Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

21 January 2018

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TRIM8/GERP RING finger protein interacts with SOCS-1

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Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

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Negative regulation of FAK signaling by SOCS proteins

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21 January 2018

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