A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box. (Q38297454)

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scientific article published on 24 August 2001

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English	A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.	scientific article published on 24 August 2001

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10 November 2019

A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box (English)

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10 November 2019

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10 November 2019

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T Hanada

1

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10 November 2019

T Yoshida

2

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10 November 2019

S Minoguchi

4

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10 November 2019

H Yasukawa

5

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10 November 2019

S Kato

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10 November 2019

H Mimata

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10 November 2019

Y Nomura

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10 November 2019

Y Seki

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10 November 2019

M Kubo

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10 November 2019

A Yoshimura

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10 November 2019

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24 August 2001

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10 November 2019

Journal of Biological Chemistry

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10 November 2019

276

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10 November 2019

44

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10 November 2019

40746-40754

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10 November 2019

STATs and Gene Regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106139200

21 January 2018

Negative regulation of cytokine signaling pathways

1 reference

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21 January 2018

Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

1 reference

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

1 reference

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Cloning and characterization of novel CIS family genes

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21 January 2018

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1 reference

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

1 reference

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Gigantism in mice lacking suppressor of cytokine signalling-2

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

1 reference

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21 January 2018

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

1 reference

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21 January 2018

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

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21 January 2018

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

1 reference

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21 January 2018

Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responses

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Control of B cell development by Ras-mediated activation of Raf.

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Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis

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The influence of the MAPK pathway on T cell lineage commitment

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STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

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21 January 2018

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1 reference

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21 January 2018

Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II

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Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

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Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

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21 January 2018

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

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Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

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CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

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Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A

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