Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme (Q24300851)

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English	Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme	scientific article

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Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Beta-secretase 1

1 reference

GOA release 2020-03-11

Sortilin related receptor 1

1 reference

GOA release 2020-03-11

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

1 reference

GOA release 2020-03-11

Sortilin-related receptor, LDLR class A repeats-containing

1 reference

GOA release 2020-03-11

Amyloid beta (A4) precursor protein

1 reference

GOA release 2020-03-11

Ithan D. Peltan

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Olav M. Andersen

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Thomas E Willnow

9

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

author name string

Robert Spoelgen

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Christine A F von Arnim

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Anne V Thomas

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Mirjam Koker

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Amy Deng

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Michael C Irizarry

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Bradley T Hyman

10

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Europe PubMed Central

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11 May 2020

language of work or name

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publication date

11 January 2006

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Journal of Neuroscience

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Europe PubMed Central

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11 May 2020

26

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

418-428

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular mechanisms of beta-amyloid production and secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and functional characterization of the mosaic receptor SorLA/LR11.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GGAs promote ARF-dependent recruitment of clathrin to the TGN

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring proteins in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of apolipoprotein E receptor LR11 in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramembrane proteolysis: theme and variations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407538

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3882-05.2006

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674411&resulttype=core&format=json

11 May 2020

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