Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus (Q24300770)

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Matthias A. Karajannis

object named as

Matthias A Karajannis

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David Zagzag

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author name string

Jonathan Cooper

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Lu Zhou

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Chenyi Yang

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C Oliver Hanemann

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Pengbo Zhou

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Filippo G Giancotti

A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer

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language of work or name

English

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publication date

14 July 2014

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48-60

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cites work

1 reference

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Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2

19 March 2017

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Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

19 March 2017

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Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

19 March 2017

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A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions

19 March 2017

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The Hippo Signaling Pathway in Development and Cancer

19 March 2017

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Involvement of Lgl and Mahjong/VprBP in cell competition

19 March 2017

1 reference

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Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

19 March 2017

1 reference

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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

19 March 2017

1 reference

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

19 March 2017

1 reference

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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

19 March 2017

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

19 March 2017

1 reference

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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

19 March 2017

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

19 March 2017

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LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

19 March 2017

1 reference

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

19 March 2017

1 reference

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

19 March 2017

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The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

19 March 2017

1 reference

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A crucial role of WW45 in developing epithelial tissues in the mouse

19 March 2017

1 reference

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

19 March 2017

1 reference

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

19 March 2017

1 reference

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Nonproteolytic functions of ubiquitin in cell signaling

19 March 2017

1 reference

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Elucidation of a universal size-control mechanism in Drosophila and mammals

7 April 2017

1 reference

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An evolutionary shift in the regulation of the Hippo pathway between mice and flies

7 April 2017

1 reference

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EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex

27 September 2017

1 reference

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Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

27 September 2017

1 reference

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FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function

27 September 2017

1 reference

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Hippo signaling: growth control and beyond

27 September 2017

1 reference

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The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

27 September 2017

1 reference

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Kibra is a regulator of the Salvador/Warts/Hippo signaling network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

27 September 2017

1 reference

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Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4126592

Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis

19 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25026211

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2014.05.001

1 reference

1 reference

1 reference

PubMed publication ID

25026211

1 reference