LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 (Q24298040)

regulation of actin filament polymerization

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Xiaolong Yang

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Kuanping Yu

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Yawei Hao

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Da-ming Li

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Rodney Stewart

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Karl L Insogna

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Tian Xu

The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae

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language of work or name

English

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publication date

July 2004

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609-17

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cites work

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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

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Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

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AIM-1: a mammalian midbody-associated protein required for cytokinesis

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Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

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Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis

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Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis

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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

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Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

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Proteins of the ADF/cofilin family: essential regulators of actin dynamics

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

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The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle

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Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis

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Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle

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Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family

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Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.

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Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma

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LATS1 tumor suppressor regulates G2/M transition and apoptosis

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Animal cell cytokinesis

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A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila

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A role for LIM kinase in cancer invasion.

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Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis

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How is actin polymerization nucleated in vivo?

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Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures

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Role of citron kinase as a target of the small GTPase Rho in cytokinesis

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Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.

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Loss of p53 and centrosome hyperamplification.

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The mitotic machinery as a source of genetic instability in cancer

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Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

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