The endoplasmic reticulum stress response in aging and age-related diseases (Q24297710)

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English	The endoplasmic reticulum stress response in aging and age-related diseases	scientific article

Statements

instance of

scholarly article

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title

The endoplasmic reticulum stress response in aging and age-related diseases (English)

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main subject

endoplasmic reticulum

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PERK-mediated unfolded protein response

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stated in

GOA release 2020-03-11

author name string

Marishka K Brown

series ordinal

1

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Nirinjini Naidoo

series ordinal

2

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language of work or name

English

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publication date

2012

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published in

Frontiers in Physiology

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stated in

Crossref

volume

3

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page(s)

263

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cites work

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

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Endoplasmic reticulum stress and atherosclerosis

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19 March 2017

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

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Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

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Folding proteins in fatal ways

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

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Perk is essential for translational regulation and cell survival during the unfolded protein response

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Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells

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Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury

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Autophagy is activated for cell survival after endoplasmic reticulum stress

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The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo

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27 September 2017

Activation of PERK signaling attenuates Abeta-mediated ER stress

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27 September 2017

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27 September 2017

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

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27 September 2017

Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.

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27 September 2017

Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase

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27 September 2017

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

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27 September 2017

Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress

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27 September 2017

Hypoxia signalling through mTOR and the unfolded protein response in cancer

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27 September 2017

From endoplasmic-reticulum stress to the inflammatory response

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27 September 2017

Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling

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27 September 2017

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27 September 2017

The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration

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27 September 2017

Autophagy in aging and in neurodegenerative disorders

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27 September 2017

Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

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27 September 2017

Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner.

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27 September 2017

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis

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27 September 2017

GRP78 induction in cancer: therapeutic and prognostic implications.

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27 September 2017

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

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27 September 2017

The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth

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27 September 2017

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

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27 September 2017

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

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27 September 2017

Stress induction of GRP78/BiP and its role in cancer.

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27 September 2017

The unfolded protein response: a stress signaling pathway critical for health and disease.

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27 September 2017

From acute ER stress to physiological roles of the Unfolded Protein Response

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27 September 2017

ER stress and the unfolded protein response

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429039

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27 September 2017

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

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PubMed Central

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27 September 2017

A cure for traffic jams: small molecule chaperones in the endoplasmic reticulum

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429039

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27 September 2017

Extensive and divergent effects of sleep and wakefulness on brain gene expression

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429039

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27 September 2017

'Unfolding' pathways in neurodegenerative disease

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27 September 2017

The endoplasmic reticulum: a multifunctional signaling organelle

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27 September 2017

Orchestrating the unfolded protein response in health and disease

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27 September 2017

Translational control in the endoplasmic reticulum stress response

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429039

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27 September 2017

Adipogenesis and aging: does aging make fat go MAD?

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429039

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27 September 2017

Transcriptional and translational control in the Mammalian unfolded protein response

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27 September 2017

Atherosclerosis: another protein misfolding disease?

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27 September 2017

Sick chaperones and ageing: a perspective

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27 September 2017

Demography. Broken limits to life expectancy

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27 September 2017

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation

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27 September 2017

Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence

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27 September 2017

Recent advances in understanding the pathogenesis of Huntington's disease

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27 September 2017

Biodemographic trajectories of longevity

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27 September 2017

Dispersion of cisternae of rough endoplasmic reticulum in aging CNS neurons: A strictly linear trend

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27 September 2017

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells

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27 September 2017

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

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30 May 2018

X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas.

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30 May 2018

Cellular environment facilitates protein accumulation in aged rat hippocampus.

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30 May 2018

Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response

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30 May 2018

Compensatory sleep response to 12 h wakefulness in young and old rats

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30 May 2018

Effect of sleep disruption on sleep, performance, and mood

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30 May 2018

Effect of age on the circadian pattern of sleep and wakefulness in the mouse

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PubMed Central

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30 May 2018

Molecular correlates of sleep and wakefulness in the brain of the white-crowned sparrow

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29 November 2018

Macromolecule biosynthesis: a key function of sleep

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29 November 2018

A role for the molecular chaperone protein BiP/GRP78 in Drosophila sleep homeostasis

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29 November 2018

Activation of the unfolded protein response in Parkinson's disease

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29 November 2018

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

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29 November 2018

The unfolded protein response is activated in Alzheimer's disease.

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29 November 2018

Sleep deprivation induces the unfolded protein response in mouse cerebral cortex

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29 November 2018

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

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29 November 2018

Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellular hydrogen peroxide and caspase 3 activation in HL-60 cells.

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29 November 2018

Age-dependent changes in recovery sleep after 48 hours of sleep deprivation in rats

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29 November 2018

Correlates of sleep and waking in Drosophila melanogaster

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29 November 2018

Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions

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12 December 2020

based on heuristic

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Daytime sleepiness: quantification of a behavioral state

1 reference

stated in

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https://pubmed.ncbi.nlm.nih.gov/22934019

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unfolded protein response is required for haploid tolerance in yeast

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22934019

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22934019

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.3389/FPHYS.2012.00263

0 references

PMC publication ID

3429039

0 references

PubMed publication ID

22934019

0 references

ResearchGate publication ID

230763805

0 references

 

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