FMS-like tyrosine kinase 3 (Q14912405)

Immunoglobulin-like fold

1 reference

Protein kinase-like domain superfamily

1 reference

Immunoglobulin-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Protein kinase domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, receptor class III, conserved site, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Immunoglobulin domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

phosphatidylinositol 3-kinase binding

1 reference

14 February 2019

Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

protein binding

6 references

14 February 2019

Identification and characterization of a functional murine FLT3 isoform produced by exon skipping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

14 February 2019

Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

ubiquitin protein ligase binding

1 reference

14 February 2019

The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cytokine receptor activity

1 reference

14 February 2019

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

protein self-association

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

glucocorticoid receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

10 September 2018

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

transmembrane signaling receptor activity

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

transmembrane receptor protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

endoplasmic reticulum lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

external side of plasma membrane

1 reference

14 February 2019

The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

integral component of plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

receptor complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cellular response to virus

biological process

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

positive regulation of protein phosphorylation

1 reference

14 February 2019

Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

antigen processing and presentation

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

positive regulation of interleukin-12 production

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

dendritic cell homeostasis

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

1 reference

7 November 2018

lymphocyte differentiation

1 reference

7 November 2018

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

positive regulation of interferon-alpha production

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

pro-T cell differentiation

1 reference

14 February 2019

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

negative regulation of interleukin-6 production

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

positive regulation of interferon-gamma production

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

spleen development

1 reference

14 February 2019

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

post-embryonic development

1 reference

14 February 2019

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

lymphoid progenitor cell differentiation

1 reference

14 February 2019

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

1 reference

14 February 2019

negative regulation of B cell differentiation

1 reference

14 February 2019

Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

positive regulation of multicellular organism growth

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

protein autophosphorylation

homeostasis of number of cells within a tissue

2 references

negative regulation of tumor necrosis factor production

2 references

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

lymph node development

1 reference

14 February 2019

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

negative regulation of cell population proliferation

1 reference

14 February 2019

Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

leukocyte homeostasis

1 reference

14 February 2019

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

B cell differentiation

1 reference

7 November 2018

Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

lymphocyte proliferation

1 reference

14 February 2019

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cytokine-mediated signaling pathway

1 reference

7 November 2018

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

pro-B cell differentiation

common myeloid progenitor cell proliferation

1 reference

14 February 2019

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

dendritic cell differentiation

1 reference

14 February 2019

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

myeloid progenitor cell differentiation

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

14 February 2019

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cellular response to cytokine stimulus

1 reference

14 February 2019

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

negative regulation of signal transduction

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

negative regulation of apoptotic process

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00342&geneProductId=UniProtKB:Q00342

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

hematopoietic progenitor cell differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

leukocyte differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

positive regulation of cell population proliferation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

cytokine-mediated signaling pathway

lymphocyte differentiation

positive regulation of MAPK cascade

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00342

has part(s)

immunoglobulin subtype

1 reference

tyrosine-protein kinase, receptor class III, conserved site

1 reference

immunoglobulin domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

immunoglobulin-like domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference