Paired-like homeobox 2b (Q14905597)

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mammalian protein found in Mus musculus

NBPhox
Phox2b
paired mesoderm homeobox 2b
dilated pupils 1
Paired-like homeobox 2B
paired mesoderm homeobox protein 2B
PHOX2B homeodomain protein
neuroblastoma Phox
GENA 269

Language	Label	Description	Also known as
English	Paired-like homeobox 2b	mammalian protein found in Mus musculus	NBPhox Phox2b paired mesoderm homeobox 2b dilated pupils 1 Paired-like homeobox 2B paired mesoderm homeobox protein 2B PHOX2B homeodomain protein neuroblastoma Phox GENA 269

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35690

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

sequence-specific DNA binding

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method or standard

4 references

31 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

determination method or standard

5 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

1 January 2018

The Hlx homeobox transcription factor is required early in enteric nervous system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

1 January 2018

Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

1 January 2018

A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

determination method or standard

6 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

The Hlx homeobox transcription factor is required early in enteric nervous system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

biological process

sympathetic ganglion development

determination method or standard

1 reference

14 February 2019

Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

noradrenergic neuron development

determination method or standard

1 reference

14 February 2019

Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

dopaminergic neuron differentiation

determination method or standard

1 reference

14 February 2019

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

negative regulation of neuron differentiation

determination method or standard

1 reference

14 February 2019

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

sympathetic nervous system development

determination method or standard

1 reference

14 February 2019

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

cell development

determination method or standard

1 reference

14 February 2019

The role of Phox2B in chromaffin cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

parasympathetic nervous system development

determination method or standard

1 reference

14 February 2019

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

retrotrapezoid nucleus neuron differentiation

determination method or standard

1 reference

14 February 2019

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

brainstem development

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

cellular response to BMP stimulus

determination method or standard

1 reference

14 February 2019

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

neuron migration

determination method or standard

1 reference

14 February 2019

Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

glial cell differentiation

determination method or standard

1 reference

14 February 2019

Signals from the neural crest regulate beta-cell mass in the pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

efferent axon development in a lateral line nerve

determination method or standard

1 reference

14 February 2019

Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

multicellular organism development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

regulation of respiratory gaseous exchange by nervous system process

determination method or standard

1 reference

14 February 2019

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

cell differentiation in hindbrain

determination method or standard

1 reference

14 February 2019

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

neural crest cell migration involved in autonomic nervous system development

determination method or standard

1 reference

14 February 2019

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

positive regulation of neuron differentiation

determination method or standard

1 reference

14 February 2019

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

neuron differentiation

determination method or standard

1 reference

14 February 2019

Signals from the neural crest regulate beta-cell mass in the pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

respiratory system development

determination method or standard

1 reference

14 February 2019

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

skeletal muscle cell differentiation

determination method or standard

1 reference

14 February 2019

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

regulation of gene expression

determination method or standard

1 reference

14 February 2019

Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

inner ear development

determination method or standard

1 reference

14 February 2019

Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

medullary reticular formation development

determination method or standard

1 reference

14 February 2019

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

hindbrain tangential cell migration

determination method or standard

1 reference

14 February 2019

Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

14 February 2019

Signals from the neural crest regulate beta-cell mass in the pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

31 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35690&geneProductId=UniProtKB:O35690

determination method or standard

positive regulation of cold-induced thermogenesis

determination method or standard

1 reference

14 February 2019

Impaired ventilatory and thermoregulatory responses to hypoxic stress in newborn phox2b heterozygous knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

nervous system development

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

autonomic nervous system development

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

enteric nervous system development

determination method or standard

3 references

14 February 2019

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35690

determination method or standard

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35690

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35690

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000012664

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000012664

ENSMUSP00000134216

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000134216

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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