Pages that link to "Q37961792"
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The following pages link to γ-Secretase inhibitors and modulators for Alzheimer's disease (Q37961792):
Displaying 50 items.
- Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage (Q27014952) (← links)
- A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP (Q27314017) (← links)
- Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration (Q27331605) (← links)
- Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy (Q28536678) (← links)
- γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ (Q28687678) (← links)
- Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? (Q28828789) (← links)
- Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data (Q30584453) (← links)
- Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes (Q31057900) (← links)
- SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. (Q33645235) (← links)
- Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition (Q34292546) (← links)
- A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease (Q34376103) (← links)
- Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa (Q34498158) (← links)
- Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. (Q34656871) (← links)
- Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes (Q35037737) (← links)
- Cutting in on a secretase pas de deux (Q35769880) (← links)
- Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. (Q36024533) (← links)
- Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping. (Q36028390) (← links)
- A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease (Q36768052) (← links)
- Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant? (Q36939128) (← links)
- Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation (Q37368658) (← links)
- What's hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders (Q38038399) (← links)
- Notch-directed microenvironment reprogramming in myeloma: a single path to multiple outcomes (Q38073136) (← links)
- The very many faces of presenilins and the γ-secretase complex. (Q38090514) (← links)
- Development and mechanism of γ-secretase modulators for Alzheimer's disease (Q38101383) (← links)
- Alzheimer disease: current concepts & future directions. (Q38166416) (← links)
- α-Mangostin decreases β-amyloid peptides production via modulation of amyloidogenic pathway. (Q38827287) (← links)
- Perspectives for treating Alzheimer's disease: a review on promising pharmacological substances (Q38936146) (← links)
- Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig. (Q39087660) (← links)
- New flurbiprofen derivatives: synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels (Q39100139) (← links)
- Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor (Q39181374) (← links)
- Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside (Q39736750) (← links)
- Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts (Q41748072) (← links)
- Modulation of gamma-secretase for the treatment of Alzheimer's disease (Q42286536) (← links)
- Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein (Q42578574) (← links)
- CNTF, STAT3 and new therapies for axonal degeneration: what are they and what can they do? (Q43501999) (← links)
- CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice. (Q45912487) (← links)
- Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model (Q46527301) (← links)
- One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp3)-H activations. (Q48348195) (← links)
- Decrease of Amyloid-β Levels by Curcumin Derivative via Modulation of Amyloid-β Protein Precursor Trafficking (Q48393510) (← links)
- [(3) H]-L685,458 binding sites are abundant in multiple peripheral organs in rats: implications for safety assessment of putative γ-secretase targeting drugs (Q48767057) (← links)
- Small molecules intercept Notch signaling and the early secretory pathway (Q50719014) (← links)
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects. (Q53459259) (← links)
- Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness. (Q53466041) (← links)
- Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation. (Q55669261) (← links)
- Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays (Q60303067) (← links)
- Genomics: New Light on Alzheimer's Disease Research (Q60935279) (← links)
- BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease (Q64077439) (← links)
- Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm (Q90149561) (← links)
- Dendrobium alkaloids decrease Aβ by regulating α- and β-secretases in hippocampal neurons of SD rats (Q90171500) (← links)
- Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration (Q90477691) (← links)