Unfolded protein response in cancer: the physician's perspective (Q37846249)

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scientific article published on 23 February 2011

Language	Label	Description	Also known as
English	Unfolded protein response in cancer: the physician's perspective	scientific article published on 23 February 2011

Statements

instance of

scholarly article

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

review article

1 reference

stated in

PubMed

retrieved

3 April 2019

title

Unfolded protein response in cancer: the physician's perspective (English)

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

main subject

cancer

1 reference

stated in

PubMed

retrieved

3 April 2019

author name string

Xuemei Li

series ordinal

1

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

Kezhong Zhang

series ordinal

2

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

Zihai Li

series ordinal

3

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

publication date

23 February 2011

2 references

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

stated in

PubMed Central

retrieved

3 April 2019

published in

Journal of Hematology & Oncology

2 references

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

stated in

PubMed Central

retrieved

3 April 2019

volume

4

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

page(s)

8

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

copyright license

Creative Commons Attribution 2.0 Generic

1 reference

stated in

Europe PubMed Central

retrieved

3 April 2019

on focus list of Wikimedia project

ScienceSource

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ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

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Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

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Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

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Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus

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Inhibition of p97-dependent protein degradation by Eeyarestatin I

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Cannabinoids and gliomas.

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The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

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Translational control and the unfolded protein response

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The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

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Endoplasmic reticulum stress triggers autophagy

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The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth

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"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways

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Stress induction of GRP78/BiP and its role in cancer.

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From acute ER stress to physiological roles of the Unfolded Protein Response

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The mammalian unfolded protein response

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

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The role of the unfolded protein response in tumour development: friend or foe?

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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

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Regulation of apoptosis by endoplasmic reticulum pathways.

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Cannabinoids: potential anticancer agents

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6 September 2017

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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The Clinical Applications of Heat Shock Protein Inhibitors in Cancer - Present and Future

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Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

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Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

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6 September 2017

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

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6 September 2017

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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6 September 2017

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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6 September 2017

Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans

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PubMed Central

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6 September 2017

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

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6 September 2017

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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6 September 2017

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

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6 September 2017

Perk is essential for translational regulation and cell survival during the unfolded protein response

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PubMed Central

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6 September 2017

Tripartite management of unfolded proteins in the endoplasmic reticulum

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6 September 2017

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

6 September 2017

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

6 September 2017

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

6 September 2017

Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

6 September 2017

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

6 September 2017

Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

The cellular response to unfolded proteins: intercompartmental signaling

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

14 September 2017

Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

28 September 2017

Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

23 June 2018

Regulation of apoptosis by the unfolded protein response.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

23 June 2018

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

23 June 2018

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

23 June 2018

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

23 June 2018

Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

23 June 2018

A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. structure elucidation

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

The unfolded protein response: an intracellular signalling pathway with many surprising features

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060154

retrieved

1 September 2018

Identifiers

DOI

10.1186/1756-8722-4-8

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

PMC publication ID

3060154

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

PubMed publication ID

21345215

1 reference

stated in

Europe PubMed Central

PMC publication ID

3060154

retrieved

24 August 2017

ResearchGate publication ID

49942616

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