Cannabinoids: potential anticancer agents (Q34542671)

2 August 2017

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title

Cannabinoids: potential anticancer agents (English)

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2 August 2017

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Manuel Guzmán

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14570037

23 March 2024

language of work or name

English

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publication date

1 October 2003

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full work available at URL

2 August 2017

http://www.nature.com/articles/nrc1188.pdf

file format

Portable Document Format

1 reference

http://www.nature.com/articles/nrc1188

23 March 2024

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23 March 2024

published in

Nature Reviews Cancer

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

745-755

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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

2 August 2017

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A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding.

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The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells

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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

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Control of pain initiation by endogenous cannabinoids.

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Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review

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Cannabinoids: a real prospect for pain relief?

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The therapeutic potential of cannabis in multiple sclerosis

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Antineoplastic Activity of Cannabinoids2

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Cannabinoids and cell fate.

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Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1

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Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression

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The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase

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Cannabinoids activate p38 mitogen-activated protein kinases through CB1 receptors in hippocampus

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Mammalian MAP kinase signalling cascades

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The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway.

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Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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Differential roles of CB1 and CB2 cannabinoid receptors in mast cells

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De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.

31 March 2020

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A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

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Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.

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Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.

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Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.

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The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.

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Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

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Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.

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Ceramide: a new second messenger of cannabinoid action

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Anti‐proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: Implication of epidermal growth factor receptor down‐regulation and ceramide production

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Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3

31 March 2020

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ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death

31 March 2020

1 reference

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.

31 March 2020

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Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells

31 March 2020

1 reference

Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation.

31 March 2020

1 reference

Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth

31 March 2020

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Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors

31 March 2020

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Clinical translation of angiogenesis inhibitors

31 March 2020

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Inhibition of tumor angiogenesis by cannabinoids

31 March 2020

1 reference

Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis

31 March 2020

1 reference

Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway

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Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling.

31 March 2020

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De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase

31 March 2020

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Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.

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Cannabinoids and brain injury: therapeutic implications

31 March 2020

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Acute neuronal injury, excitotoxicity, and the endocannabinoid system

31 March 2020

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Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors

31 March 2020

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Control of the cell survival/death decision by cannabinoids

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Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis

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Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway

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Cannabinoids enhance human B-cell growth at low nanomolar concentrations

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31 March 2020

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31 March 2020

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31 March 2020

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Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase

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Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells

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31 March 2020

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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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Structure of a cannabinoid receptor and functional expression of the cloned cDNA

31 March 2020

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Molecular characterization of a peripheral receptor for cannabinoids

31 March 2020

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Formation and inactivation of endogenous cannabinoid anandamide in central neurons

31 March 2020

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A second endogenous cannabinoid that modulates long-term potentiation

31 March 2020

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31 March 2020

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31 March 2020

1 reference

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

31 March 2020

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31 March 2020

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31 March 2020

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5784

C Sanchez

2001

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23 March 2024

Molecular Pharmacology

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S Mukhopadhyay

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Journal of Pharmacology and Experimental Therapeutics

23 March 2024

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W Zhu

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23 March 2024

Identifiers

DOI

10.1038/NRC1188

1 reference

Dimensions Publication ID

2 August 2017

1023364365

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Fatcat ID

release_qqpo4ayjwrgaxdmlttji4ikzfy

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Fatcat

https://api.fatcat.wiki/v0/release/qqpo4ayjwrgaxdmlttji4ikzfy

mapped directly with Wikidata item

24 November 2022

based on heuristic

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