The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis (Q37292195)

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scientific article published on 21 April 2009

Language	Label	Description	Also known as
English	The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis	scientific article published on 21 April 2009

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1 reference

21 December 2020

The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

cell surface receptor

1 reference

31 July 2019

breast neoplasm

7 references

31 July 2019

28 September 2019

20 November 2019

28 November 2019

15 December 2019

26 August 2020

21 December 2020

1 reference

28 September 2019

1 reference

20 November 2019

transport protein

1 reference

28 November 2019

membrane protein

1 reference

15 December 2019

signal transduction

1 reference

26 August 2020

guanine nucleotide exchange factors

1 reference

21 December 2020

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Hisataka Sabe

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Shigeru Hashimoto

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Masaki Morishige

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Eiji Ogawa

4

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Ari Hashimoto

5

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Jin-Min Nam

6

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Koichi Miura

7

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Hajime Yano

8

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Yasuhito Onodera

9

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

21 April 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1 August 2009

10 references

13 March 2019

3 April 2019

17 June 2019

31 July 2019

28 September 2019

20 November 2019

28 November 2019

15 December 2019

26 August 2020

21 December 2020

11 references

Europe PubMed Central

PMC publication ID

19 August 2017

13 March 2019

3 April 2019

17 June 2019

31 July 2019

28 September 2019

20 November 2019

28 November 2019

15 December 2019

26 August 2020

21 December 2020

10

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

982-993

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

copyright license

Creative Commons Attribution 2.5 Generic

10 references

Europe PubMed Central

13 March 2019

Europe PubMed Central

3 April 2019

Europe PubMed Central

17 June 2019

Europe PubMed Central

31 July 2019

Europe PubMed Central

28 September 2019

Europe PubMed Central

20 November 2019

Europe PubMed Central

28 November 2019

Europe PubMed Central

15 December 2019

Europe PubMed Central

26 August 2020

Europe PubMed Central

21 December 2020

on focus list of Wikimedia project

0 references

Fbx8 makes Arf6 refractory to function via ubiquitination.

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GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.

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Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts.

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Src-dependent phosphorylation of ASAP1 regulates podosomes

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CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery

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GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin

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Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis

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Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis

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ARF proteins: roles in membrane traffic and beyond

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A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor

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Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic

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Regulation of cadherin-mediated adhesion in morphogenesis

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DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma

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E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation

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Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities

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Systematic analysis and nomenclature of mammalian F-box proteins

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Stable 'portrait' of breast tumors during progression: data from biology, pathology and genetics

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The SCF ubiquitin ligase: insights into a molecular machine

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ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway

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CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors

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Requirement for Arf6 in breast cancer invasive activities

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Cadherin cell adhesion receptors as a morphogenetic regulator

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The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

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Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop

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Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

14 September 2017

ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

14 September 2017

The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

14 September 2017

Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

28 September 2017

A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

28 September 2017

Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

28 September 2017

Assays and properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

26 June 2018

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

26 June 2018

Prognostic models in melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

26 June 2018

IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

The prognostic role of a gene signature from tumorigenic breast-cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

Differential modification of Ras proteins by ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

DNA copy number changes at 8q11-24 in metastasized colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 September 2018

Getting invasive with GEP100 and Arf6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721971

3 December 2018

Integration of EGFR inhibitors with radiochemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19416474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorting out breast-cancer gene signatures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19416474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of c-erbB-2/neu amplification and epidermal growth factor receptor (EGFR) in primary breast cancer and their relation to estradiol receptor (ER) status

1 reference

https://pubmed.ncbi.nlm.nih.gov/19416474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19416474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19416474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19416474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1600-0854.2009.00917.X

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

ResearchGate publication ID

0 references

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