Mitochondriotoxic compounds for cancer therapy (Q36558020)

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scientific article published on August 2006

Language	Label	Description	Also known as
English	Mitochondriotoxic compounds for cancer therapy	scientific article published on August 2006

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

1 reference

Europe PubMed Central

Mitochondriotoxic compounds for cancer therapy (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

author name string

Fantin VR

1

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Leder P

2

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

language of work or name

0 references

publication date

1 August 2006

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

34

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

4787-4797

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells.

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Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines

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Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

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Mitochondria and cell death. Mechanistic aspects and methodological issues

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The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

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Particle assembly incorporating a VP22-BH3 fusion protein, facilitating intracellular delivery, regulated release, and apoptosis

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Anti-microbial peptides: from invertebrates to vertebrates.

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Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors

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Mitochondrial Membrane Potential in Living Cells

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The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

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ANT2 isoform required for cancer cell glycolysis

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Calcium signaling

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The Bcl2 family: regulators of the cellular life-or-death switch

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Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

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tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane

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Oncogenic alterations of metabolism

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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Targeted proapoptotic LHRH-BH3 peptide

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A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution

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A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

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Anti-cancer activity of targeted pro-apoptotic peptides

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

1 reference

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Mechanisms for the modulation of membrane bilayer properties by amphipathic helical peptides

1 reference

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A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells

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A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

1 reference

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Genetic dissection of the permeability transition pore

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Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

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Targeting programmed cell death pathways with experimental therapeutics: opportunities in high-risk neuroblastoma

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PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor

1 reference

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Mitochondria and apoptosis

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Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model

1 reference

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The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death.

1 reference

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Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

1 reference

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Superoxide dismutase as a target for the selective killing of cancer cells

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Radioresistance in carcinoma of the breast

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bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

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De novo antimicrobial peptides with low mammalian cell toxicity

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Apoptosis: a link between cancer genetics and chemotherapy

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Intrinsic and extrinsic uncoupling of oxidative phosphorylation

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The concept of synthetic lethality in the context of anticancer therapy

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Effect of the lipophilic/hydrophilic character of cationic triarylmethane dyes on their selective phototoxicity toward tumor cells

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Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer

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Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries

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Reactive oxygen species and mitochondrial diseases

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Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

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Dysregulation of apoptosis genes in hematopoietic malignancies.

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Reversal of obesity by targeted ablation of adipose tissue

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The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

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Introduction: mitochondrial control of apoptosis

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The mitochondrial death/life regulator in apoptosis and necrosis

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Arsenic trioxide, a novel mitochondriotoxic anticancer agent?

1 reference

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Mitochondrial control of cell death

1 reference

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Bcl-2-family proteins and the role of mitochondria in apoptosis

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Photophysical, photochemical, and tumor-selectivity properties of bromine derivatives of rhodamine-123.

1 reference

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Pore protein and the hexokinase-binding protein from the outer membrane of rat liver mitochondria are identical

1 reference

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Hypersensitization of tumor cells to glycolytic inhibitors

1 reference

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Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells

1 reference

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Translocation of loops regulates transport activity of mitochondrial ADP/ATP carrier deduced from formation of a specific intermolecular disulfide bridge catalyzed by copper-o-phenanthroline.

1 reference

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Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide

1 reference

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Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore

1 reference

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Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells

1 reference

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To use MIBI or not to use MIBI? That is the question when assessing tumour cells

1 reference

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INTRAMITOCHONDRIAL FIBERS WITH DNA CHARACTERISTICS. I. FIXATION AND ELECTRON STAINING REACTIONS

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Mitochondria: releasing power for life and unleashing the machineries of death

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

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Mitochondrial superoxide dismutase: a promising target for new anticancer therapies

1 reference

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7 January 2021

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Hexokinase II: the integration of energy metabolism and control of apoptosis

1 reference

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7 January 2021

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Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

1 reference

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7 January 2021

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ROS stress in cancer cells and therapeutic implications

1 reference

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7 January 2021

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Phase I trial of the selective mitochondrial toxin MKT 077 in chemo-resistant solid tumours

1 reference

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7 January 2021

based on heuristic

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Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondria, the killer organelles and their weapons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

inferred from DOI database lookup

Dysregulation of apoptosis in cancer

1 reference

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7 January 2021

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BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense

1 reference

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7 January 2021

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DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells

1 reference

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7 January 2021

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Cellular energy utilization and molecular origin of standard metabolic rate in mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

inferred from DOI database lookup

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA damage by anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Mitochondrial DNA determines the cellular response to cancer therapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Delivery of bioactive molecules to mitochondria in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

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Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

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Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

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Intracellular distribution of a platinum-rhodamine 123 complex in cis-platinum sensitive and resistant human squamous carcinoma cell lines.

1 reference

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7 January 2021

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A predictive model for the selective accumulation of chemicals in tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

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7 January 2021

based on heuristic

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The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

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7 January 2021

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Mitochondrial pharmaceutics

1 reference

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7 January 2021

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Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy

1 reference

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7 January 2021

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Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Mitochondrial permeability transition in apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

based on heuristic

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Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

1 reference

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7 January 2021

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Identifiers

10.1038/SJ.ONC.1209599

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

ResearchGate publication ID

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