Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid (Q57243601)

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7 December 2019

title

Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid (English)

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7 December 2019

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7 December 2019

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7 December 2019

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7 December 2019

Klaus-Michael Debatin

series ordinal

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7 December 2019

G Kroemer

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7 December 2019

C Scaffidi

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7 December 2019

P H Krammer

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7 December 2019

language of work or name

English

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publication date

1 December 1998

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Journal of Biological Chemistry

7 December 2019

published in

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7 December 2019

volume

273

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7 December 2019

issue

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7 December 2019

page(s)

33942-33948

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Apoptosis in cancer therapy: crossing the threshold

7 December 2019

cites work

1 reference

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Mitochondrial control of apoptosis

21 January 2018

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The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

21 January 2018

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Mitochondrial permeability transition is a central coordinating event of apoptosis

21 January 2018

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Mitochondrial control of nuclear apoptosis.

21 January 2018

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

21 January 2018

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

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The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins

21 January 2018

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The proto-oncogene Bcl-2 and its role in regulating apoptosis

21 January 2018

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Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

21 January 2018

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Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

21 January 2018

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Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

21 January 2018

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Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells

21 January 2018

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Cytotoxic Drugs, Programmed Cell Death, and the Immune System: Defining New Roles in an Old Play

21 January 2018

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Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

21 January 2018

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Monoclonal antibody-mediated tumor regression by induction of apoptosis.

21 January 2018

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Apoptosis by death factor

21 January 2018

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

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FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

21 January 2018

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

21 January 2018

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Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

21 January 2018

1 reference

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

21 January 2018

1 reference

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FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.33942

Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.51.33942

Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex.

21 January 2018

1 reference

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Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells

21 January 2018

1 reference

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Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation

21 January 2018

1 reference

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

1 reference

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.51.33942

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852046%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852046%20AND%20SRC:MED&resulttype=core&format=json