Insulin as an autoantigen in NOD/human diabetes (Q36499414)

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Language	Label	Description	Also known as
English	Insulin as an autoantigen in NOD/human diabetes	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

Europe PubMed Central

Insulin as an autoantigen in NOD/human diabetes (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

based on heuristic

inferred from title

George Eisenbarth

3

object named as

George S Eisenbarth

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Li Zhang

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Maki Nakayama

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

publication date

1 February 2008

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Current Opinion in Immunology

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

20

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

111-118

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Screening for insulitis in adult autoantibody-positive organ donors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Autoantibody markers for the diagnosis and prediction of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Identification of naturally processed HLA-A2--restricted proinsulin epitopes by reverse immunology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Projection of an immunological self shadow within the thymus by the aire protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

T cell receptor restriction of diabetogenic autoimmune NOD T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

30 September 2017

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

28 June 2018

T-lymphocyte clone specific for pancreatic islet antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

28 June 2018

An immunologic homunculus for type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

T cell epitope mapping study with insulin overlapping peptides using ELISPOT assay in Japanese children and adolescents with type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

Maternal factors in a model of type 1 diabetes differentially affect the development of insulitis and overt diabetes in offspring.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

Insulin allergy; desensitization with crystalline zinc-insulin and steroid tapering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

21 September 2018

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268871

4 December 2018

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patients with Graves' disease who developed insulin autoimmune syndrome (Hirata disease) possess HLA-Bw62/Cw4/DR4 carrying DRB1*0406

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin desensitization with insulin lispro and an insulin pump in a 5-year-old child

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Insulin allergy: background, diagnosis and treatment]

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgG(4)-mediated allergic reaction to glargine insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide and major histocompatibility complex-specific breaking of humoral tolerance to native insulin with the B9-23 peptide in diabetes-prone and normal mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin autoantibody isotypes during the prediabetic process in young children with increased genetic risk of type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18178393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.COI.2007.11.005

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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