The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). (Q35773939)

From Wikidata

Jump to navigation Jump to search

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

scientific article published on 19 December 2011

Language	Label	Description	Also known as
English	The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).	scientific article published on 19 December 2011

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

hypermethylation

1 reference

based on heuristic

inferred from title

Capucine Van Rechem

object named as

Capucine Van Rechem

4

0 references

Dominique Leprince

object named as

Dominique Leprince

6

0 references

author name string

Bénédicte Foveau

1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Gaylor Boulay

2

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Sébastien Pinte

3

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Brian R Rood

5

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

language of work or name

0 references

publication date

19 December 2011

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

287

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

5366-5378

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Loss of Hypermethylated in Cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through β-2 adrenergic receptor (ADRB2) misregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

EphA receptor signaling--complexity and emerging themes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Ephs and ephrins in cancer: ephrin-A1 signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Inactivation of EphA2 promotes tight junction formation and impairs angiogenesis in brain endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Emerging strategies for EphA2 receptor targeting for cancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Cell adhesion and EGFR activation regulate EphA2 expression in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Eph receptors in breast cancer: roles in tumor promotion and tumor suppression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Eph receptors and Ephrins in cancer: common themes and controversies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

HIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Eph-ephrin bidirectional signaling in physiology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

EphA2 is an essential mediator of UV radiation-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

The epigenomics of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

A conditional feedback loop regulates Ras activity through EphA2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

The clinical significance of EphA2 and Ephrin A-1 in epithelial ovarian carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Eph receptor tyrosine kinases in tumor and tumor microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Eph receptor tyrosine kinases in angiogenesis: from development to disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

https://api.crossref.org/works/10.1074%2FJBC.M111.329466

21 January 2018

Mechanisms and functions of Eph and ephrin signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

MCF-10A-NeoST: a new cell system for studying cell-ECM and cell-cell interactions in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

12 July 2018

Analysis of HIC-1 methylation and transcription in human ependymomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.329466

21 January 2018

Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.329466

21 January 2018

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.329466

21 January 2018

Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.329466

21 January 2018

Ligand binding up-regulates EphA2 messenger RNA through the mitogen-activated protein/extracellular signal-regulated kinase pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

25 September 2018

c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

25 September 2018

Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

25 September 2018

Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

25 September 2018

EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

25 September 2018

Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

25 September 2018

Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22184117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced HIC-1 gene expression in non-small cell lung cancer and its clinical significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22184117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/22184117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history

1 reference

https://pubmed.ncbi.nlm.nih.gov/22184117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E-cadherin regulates the function of the EphA2 receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22184117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.329466

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35773939&oldid=1532936161"