The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). (Q35773939)

10 August 2017

title

The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). (English)

1 reference

10 August 2017

1 reference

Capucine Van Rechem

0 references

Dominique Leprince

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Bénédicte Foveau

1 reference

10 August 2017

Gaylor Boulay

series ordinal

1 reference

10 August 2017

Sébastien Pinte

series ordinal

1 reference

10 August 2017

Brian R Rood

series ordinal

1 reference

10 August 2017

language of work or name

English

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publication date

19 December 2011

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Journal of Biological Chemistry

10 August 2017

published in

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10 August 2017

volume

287

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10 August 2017

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10 August 2017

page(s)

5366-5378

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Loss of Hypermethylated in Cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through β-2 adrenergic receptor (ADRB2) misregulation

10 August 2017

cites work

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Inactivation of EphA2 promotes tight junction formation and impairs angiogenesis in brain endothelial cells

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Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice

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Emerging strategies for EphA2 receptor targeting for cancer therapeutics

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Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma

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Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells

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A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.

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12 July 2018

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Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.

12 July 2018

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EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

12 July 2018

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Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis

12 July 2018

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Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).

12 July 2018

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Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis

12 July 2018

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12 July 2018

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Eph receptors and Ephrins in cancer: common themes and controversies.

12 July 2018

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The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting

12 July 2018

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Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction

12 July 2018

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HIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumors

12 July 2018

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12 July 2018

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Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.

12 July 2018

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EphA2 is an essential mediator of UV radiation-induced apoptosis

12 July 2018

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Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.

12 July 2018

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The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

12 July 2018

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DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function

12 July 2018

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Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility

12 July 2018

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The epigenomics of cancer

12 July 2018

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Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells

12 July 2018

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A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP

12 July 2018

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Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.

12 July 2018

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

12 July 2018

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A conditional feedback loop regulates Ras activity through EphA2.

12 July 2018

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The clinical significance of EphA2 and Ephrin A-1 in epithelial ovarian carcinomas

12 July 2018

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EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

12 July 2018

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Eph receptor tyrosine kinases in tumor and tumor microenvironment

12 July 2018

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Eph receptor tyrosine kinases in angiogenesis: from development to disease.

12 July 2018

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The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer

12 July 2018

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12 July 2018

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Mechanisms and functions of Eph and ephrin signalling

21 January 2018

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The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

MCF-10A-NeoST: a new cell system for studying cell-ECM and cell-cell interactions in breast cancer

12 July 2018

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Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes.

12 July 2018

1 reference

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Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis

12 July 2018

1 reference

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p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

12 July 2018

1 reference

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Analysis of HIC-1 methylation and transcription in human ependymomas

12 July 2018

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Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors

21 January 2018

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

21 January 2018

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Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis

21 January 2018

1 reference

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Ligand binding up-regulates EphA2 messenger RNA through the mitogen-activated protein/extracellular signal-regulated kinase pathway.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285316

Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta

25 September 2018

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12 December 2020

Reduced HIC-1 gene expression in non-small cell lung cancer and its clinical significance

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12 December 2020

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays

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12 December 2020

DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history

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12 December 2020

E-cadherin regulates the function of the EphA2 receptor tyrosine kinase

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12 December 2020

Identifiers

DOI

10.1074/JBC.M111.329466

1 reference

10 August 2017

1 reference

10 August 2017

1 reference