Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy. (Q34431441)

2 August 2017

title

Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy. (English)

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2 August 2017

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Andras Heczey

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2 August 2017

Daofeng Liu

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2 August 2017

Gengwen Tian

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2 August 2017

Amy N Courtney

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2 August 2017

Jie Wei

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2 August 2017

Ekaterina Marinova

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2 August 2017

Xiuhua Gao

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2 August 2017

Linjie Guo

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2 August 2017

Eric Yvon

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2 August 2017

John Hicks

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2 August 2017

Hao Liu

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2 August 2017

Gianpietro Dotti

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2 August 2017

Leonid S Metelitsa

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2 August 2017

publication date

21 July 2014

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2 August 2017

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2 August 2017

volume

124

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2 August 2017

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2 August 2017

page(s)

2824-2833

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Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia

2 August 2017

cites work

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6 July 2018

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CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

6 July 2018

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Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology

6 July 2018

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The basic principles of chimeric antigen receptor design

6 July 2018

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Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors.

6 July 2018

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CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

6 July 2018

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Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

6 July 2018

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Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

6 July 2018

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In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)

6 July 2018

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CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

6 July 2018

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Anti-tumor potential of type-I NKT cells against CD1d-positive and CD1d-negative tumors in humans

6 July 2018

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The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex.

6 July 2018

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Differentiation of effector CD4 T cell populations (*)

6 July 2018

1 reference

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Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?".

6 July 2018

1 reference

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Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.

6 July 2018

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Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages

6 July 2018

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Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

6 July 2018

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Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.

6 July 2018

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The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages

6 July 2018

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Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma

6 July 2018

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CD1-restricted T cells and tumor immunity

6 July 2018

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T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells

6 July 2018

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NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs.

6 July 2018

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A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

6 July 2018

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Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2

6 July 2018

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Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.

6 July 2018

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Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

The unconventional lifestyle of NKT cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution

6 July 2018

1 reference

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Paired epstein-barr virus-carrying lymphoma and lymphoblastoid cell lines Burkitt's lymphoma patients: Comparative sensitivity to non-specific and to allo-specific cytotoxic responsesin vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

Biological classification of cell lines derived from human extra-cranial neural tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215313

10.1182/BLOOD-2013-11-541235

27 October 2018

Identifiers

DOI

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2 August 2017

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2 August 2017

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