Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. (Q30361219)

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English	Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

16 September 2017

Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. (English)

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Europe PubMed Central

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16 September 2017

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based on heuristic

inferred from title

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based on heuristic

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Frank B Furnari

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25347738%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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J Hu

1

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7 June 2020

K A Muller

2

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7 June 2020

W K Cavenee

4

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7 June 2020

S R VandenBerg

5

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7 June 2020

S L Gonias

6

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7 June 2020

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27 October 2014

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16 September 2017

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7 June 2020

34

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7 June 2020

31

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7 June 2020

4078-4088

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Cellular functions regulated by phosphorylation of EGFR on Tyr845.

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A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen

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Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

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Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic

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Regulation of cell migration and invasion by specific modules of uPA: mechanistic insights and specific inhibitors

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Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas.

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Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.

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3 June 2018

Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies

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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

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3 June 2018

Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence

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3 June 2018

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients

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3 June 2018

Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling

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3 June 2018

The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice

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3 June 2018

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

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3 June 2018

uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.

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3 June 2018

Malignant astrocytic glioma: genetics, biology, and paths to treatment

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3 June 2018

Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).

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3 June 2018

Urokinase signaling through its receptor protects against anoikis by increasing BCL-xL expression levels

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3 June 2018

Novel insights into c-Src

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3 June 2018

Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator.

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3 June 2018

The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis

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3 June 2018

Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II.

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3 June 2018

A renaissance for SRC

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3 June 2018

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

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3 June 2018

Regulation of Rac1 activation by the low density lipoprotein receptor-related protein

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3 June 2018

uPAR: a versatile signalling orchestrator

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3 June 2018

STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor

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3 June 2018

Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

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3 June 2018

Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.

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Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin

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Src tyrosine kinase is a novel direct effector of G proteins.

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Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

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EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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20 June 2018

Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells.

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based on heuristic

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10.1038/ONC.2014.336

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25347738%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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7 June 2020

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Europe PubMed Central

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7 June 2020

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