Targeting Src family kinases in anti-cancer therapies: turning promise into triumph (Q27025646)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Targeting Src family kinases in anti-cancer therapies: turning promise into triumph (English)

1 reference

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18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Dihua Yu

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

1 reference

9 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

Trends in Pharmacological Sciences

18 January 2020

published in

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

122-128

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Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors

18 January 2020

cites work

1 reference

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Latent bone metastasis in breast cancer tied to Src-dependent survival signals

21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration

28 September 2017

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Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2.

28 September 2017

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Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptor-negative metastatic breast cancer

28 September 2017

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A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma

28 September 2017

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Dasatinib in previously treated metastatic colorectal cancer: a phase II trial of the University of Chicago Phase II Consortium

28 September 2017

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Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia

28 September 2017

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Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.

28 September 2017

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Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

28 September 2017

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Twist1-induced invadopodia formation promotes tumor metastasis.

28 September 2017

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Phase II study of saracatinib (AZD0530) for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC)

28 September 2017

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Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth

28 September 2017

1 reference

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ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis

28 September 2017

1 reference

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Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer

28 September 2017

1 reference

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c-Src differentially regulates the functions of microtentacles and invadopodia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Microtentacles tip the balance of cytoskeletal forces in circulating tumor cells

28 September 2017

1 reference

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Phase II Study of Dasatinib in Patients With Advanced Non–Small-Cell Lung Cancer

28 September 2017

1 reference

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Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer

28 September 2017

1 reference

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Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

28 September 2017

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Longitudinal studies of SRC family kinases in imatinib- and dasatinib-resistant chronic myelogenous leukemia patients

28 September 2017

1 reference

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Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo

28 September 2017

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Advances in targeting SRC in the treatment of breast cancer and other solid malignancies

28 September 2017

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Inhibition of Src impairs the growth of met-addicted gastric tumors.

28 September 2017

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Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment

28 September 2017

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Combining Src inhibitors and aromatase inhibitors: a novel strategy for overcoming endocrine resistance and bone loss

28 September 2017

1 reference

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Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner

28 September 2017

1 reference

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Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition

28 September 2017

1 reference

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Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (Cancer and Leukemia Group B 30602).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Src kinases as therapeutic targets for cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Nuclear EGFR contributes to acquired resistance to cetuximab

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study

28 September 2017

1 reference

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Genomic strategy for targeting therapy in castration-resistant prostate cancer

28 September 2017

1 reference

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Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab.

28 September 2017

1 reference

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Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton

28 September 2017

1 reference

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Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

The interplay between Src and integrins in normal and tumor biology

28 September 2017

1 reference

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Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK.

28 September 2017

1 reference

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A phase 2 trial of dasatinib in patients with advanced HER2-positive and/or hormone receptor-positive breast cancer.

28 September 2017

1 reference

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Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells.

28 November 2018

1 reference

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Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy

28 November 2018

1 reference

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A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium

28 November 2018

1 reference

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Are SRC family kinases responsible for imatinib- and dasatinib-resistant chronic myeloid leukemias?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675659

ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis

28 November 2018

1 reference

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10.1016/J.TIPS.2011.11.002

28 November 2018

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

22153719

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22153719%20AND%20SRC:MED&resulttype=core&format=json