Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? (Q28207052)

The TNF and TNF receptor superfamilies: integrating mammalian biology

31 March 2020

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Alternative molecular form of human T cell-specific antigen CD27 expressed upon T cell activation

31 March 2020

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Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor

31 March 2020

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Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4

31 March 2020

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Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family

31 March 2020

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Antigen-presenting cell-derived signals determine expression levels of CD70 on primed T cells

31 March 2020

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LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator

31 March 2020

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Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34

31 March 2020

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Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

31 March 2020

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OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

31 March 2020

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In Vivo Triggering Through 4-1BB Enables Th-Independent Priming of CTL in the Presence of an Intact CD28 Costimulatory Pathway

31 March 2020

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Phenotype and function of human B cells expressing CD70 (CD27 ligand)

31 March 2020

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4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells

31 March 2020

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Regulation of murine B cell growth and differentiation by CD30 ligand

31 March 2020

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LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response

31 March 2020

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Characterization of murine CD70 by molecular cloning and mAb.

31 March 2020

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Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

31 March 2020

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A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation

31 March 2020

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Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

31 March 2020

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Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival

31 March 2020

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Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

31 March 2020

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Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction

31 March 2020

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Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.

31 March 2020

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A TNF family member LIGHT transduces costimulatory signals into human T cells

31 March 2020

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CD27 is required for generation and long-term maintenance of T cell immunity

31 March 2020

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Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion

31 March 2020

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Anti-tumor immunity elicited by a recombinant vaccinia virus expressing CD70 (CD27L).

31 March 2020

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Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

31 March 2020

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OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

31 March 2020

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Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand

31 March 2020

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The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion

31 March 2020

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4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination

31 March 2020

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4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity

31 March 2020

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CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

31 March 2020

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Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

31 March 2020

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Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.

31 March 2020

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Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion

31 March 2020

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OX40 ligation enhances cell cycle turnover of Ag-activated CD4 T cells in vivo

31 March 2020

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Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo.

31 March 2020

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Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

31 March 2020

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Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway

31 March 2020

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In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

31 March 2020

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Differential clonal expansion of CD4 and CD8 T cells in response to 4-1BB ligation: contribution of 4-1BB during inflammatory responses

31 March 2020

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Defective T cell priming associated with aging can be rescued by signaling through 4-1BB (CD137).

31 March 2020

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Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection

31 March 2020

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CD30-mediated signaling promotes the development of human T helper type 2-like T cells

31 March 2020

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Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

31 March 2020

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The TNF receptor family member CD30 is not essential for negative selection

31 March 2020

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Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus

31 March 2020

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CD30-governor of memory T cells?

31 March 2020

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CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase

31 March 2020

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Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation

31 March 2020

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Retracted: Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation

31 March 2020

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4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

31 March 2020

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Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.

31 March 2020

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ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5

31 March 2020

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Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation

31 March 2020

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The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2

31 March 2020

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Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B

31 March 2020

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CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand

31 March 2020

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Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1

31 March 2020

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4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

31 March 2020

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4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells

31 March 2020

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Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

31 March 2020

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IkappaB kinases serve as a target of CD28 signaling

31 March 2020

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JNK is involved in signal integration during costimulation of T lymphocytes.

31 March 2020

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T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

31 March 2020

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

31 March 2020

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

31 March 2020

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Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo

31 March 2020

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CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.

31 March 2020

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Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients

31 March 2020

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Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand

31 March 2020

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4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy

31 March 2020

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Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis

31 March 2020

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Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40.

31 March 2020

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The CD27- subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo

31 March 2020

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OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation

31 March 2020

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Role of 4-1BB (CD137) in the functional activation of cord blood CD28(-)CD8(+) T cells.

31 March 2020

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Cutting edge: profound defect in T cell responses in TNF receptor-associated factor 2 dominant negative mice.

31 March 2020

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Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

31 March 2020

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Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses

31 March 2020

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Costimulation of human CD28- T cells by 4-1BB ligand

31 March 2020

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Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

31 March 2020

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Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

31 March 2020

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Transcriptional mechanisms underlying lymphocyte tolerance.

31 March 2020

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Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis

31 March 2020

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Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice

31 March 2020

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Involvement of CD70-CD27 interactions in the induction of experimental autoimmune encephalomyelitis

31 March 2020

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Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis

31 March 2020

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Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells

31 March 2020

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Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

31 March 2020

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Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

31 March 2020

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CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

31 March 2020

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The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

31 March 2020

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LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer

31 March 2020

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CD40 and CD70 co-stimulate a potent in vivo antitumor T cell response.

31 March 2020

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Engagement of the OX-40 receptor in vivo enhances antitumor immunity

31 March 2020

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OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases

31 March 2020

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OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor response

31 March 2020

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Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma

31 March 2020

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Tumour rejection by gene transfer of 4-1BB ligand into a CD80(+) murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells

31 March 2020

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Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

31 March 2020

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Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB.

31 March 2020

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