OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells (Q28188488)

Tumor necrosis factor receptor superfamily, member 4

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

P R Rogers

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J Song

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I Gramaglia

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N Killeen

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M Croft

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

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language of work or name

English

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publication date

September 2001

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445-55

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cites work

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7 January 2021

Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40-mediated proliferation and survival pathways

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7 January 2021

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

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7 January 2021

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.

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7 January 2021

Bcl-x and the regulation of survival in the immune system.

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7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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7 January 2021

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

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7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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7 January 2021

CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

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7 January 2021

Bcl-XL and Bcl-2 repress a common pathway of cell death

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7 January 2021

Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

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7 January 2021

Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease

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7 January 2021

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements

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7 January 2021

Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

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7 January 2021

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

1 reference

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7 January 2021

Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

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7 January 2021

The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion

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7 January 2021

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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7 January 2021

IkappaB kinases serve as a target of CD28 signaling

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7 January 2021

Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals

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7 January 2021

Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40.

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7 January 2021

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

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7 January 2021

Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation

1 reference

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7 January 2021

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

1 reference

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7 January 2021

OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

The proto-oncogene Bcl-2 and its role in regulating apoptosis

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7 January 2021

The origin and mechanism of the allograft reaction

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7 January 2021

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

1 reference

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7 January 2021

The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

The role of the CD28 receptor during T cell responses to antigen

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7 January 2021

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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7 January 2021

Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

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7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

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7 January 2021

Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

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https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

The central effectors of cell death in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

T cell co-stimulatory molecules other than CD28.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Engagement of the OX-40 receptor in vivo enhances antitumor immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900191-1

7 January 2021

10.1016/S1074-7613(01)00191-1

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

11567634

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Consolidated OpenCitations Corpus – April 2017