Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 (Q27679845)

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English	Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2	scientific article

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scholarly article

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Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 (English)

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Gabriela Chiosis

12

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8

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object named as

Pengrong Yan

2

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author name string

Pallav D Patel

1

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Paul M Seidler

3

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Hardik J Patel

4

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Weilin Sun

5

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Chenghua Yang

6

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Nanette S Que

7

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Paola Finotti

9

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Ralph A Stephani

10

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Daniel T Gewirth

11

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publication date

November 2013

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Nature Chemical Biology

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9

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11

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677-84

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3982621/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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GRP94 in ER quality control and stress responses

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An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

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GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion

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Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

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HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.

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10.1038/NCHEMBIO.1335

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