Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor. (Q50173304)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467918%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor (English)

1 reference

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17 March 2020

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17 March 2020

Jonathan M Yingling

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17 March 2020

William T McMillen

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17 March 2020

Lei Yan

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17 March 2020

J Scott Sawyer

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17 March 2020

Jeremy Graff

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17 March 2020

David K Clawson

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17 March 2020

Karen S Britt

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17 March 2020

Bryan D Anderson

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17 March 2020

Douglas W Beight

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17 March 2020

Durisala Desaiah

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17 March 2020

Michael M Lahn

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17 March 2020

Karim A Benhadji

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17 March 2020

Maria J Lallena

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17 March 2020

Rikke B Holmgaard

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17 March 2020

Xiaohong Xu

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17 March 2020

Faming Zhang

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17 March 2020

Jason R Manro

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17 March 2020

Philip W Iversen

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17 March 2020

Chandrasekar V Iyer

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17 March 2020

Rolf A Brekken

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17 March 2020

Michael D Kalos

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17 March 2020

Kyla E Driscoll

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17 March 2020

language of work or name

English

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publication date

31 December 2017

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17 March 2020

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17 March 2020

volume

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17 March 2020

issue

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17 March 2020

page(s)

6659-6677

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A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

17 March 2020

cites work

1 reference

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Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

22 May 2018

1 reference

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First-in-human dose study of the novel transforming growth factor-β receptor I kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma

22 May 2018

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22 May 2018

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Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

22 May 2018

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22 May 2018

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22 May 2018

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Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells

22 May 2018

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22 May 2018

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LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

22 May 2018

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Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice

22 May 2018

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22 May 2018

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Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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14 August 2018

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Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent

14 August 2018

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Circulating transforming growth factor-beta-1 and breast cancer prognosis: results from the Shanghai Breast Cancer Study.

14 August 2018

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Differentiation plasticity regulated by TGF-beta family proteins in development and disease

14 August 2018

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The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

14 August 2018

1 reference

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Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.

14 August 2018

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Elevated plasma TGF-beta1 levels correlate with decreased survival of metastatic breast cancer patients

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29467918

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.23795

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467918%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467918%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

29467918

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29467918%20AND%20SRC:MED&resulttype=core&format=json