Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity (Q42811215)

7 November 2017

title

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity (English)

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7 November 2017

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7 November 2017

Gareth J Inman

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Francisco J Nicolás

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7 November 2017

publication date

1 August 2002

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7 November 2017

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7 November 2017

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7 November 2017

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7 November 2017

page(s)

283-294

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Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

7 November 2017

cites work

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

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7 January 2021

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

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7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Microtubule binding to Smads may regulate TGF beta activity

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Continuous recycling: a mechanism for modulatory signal transduction

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Differential usage of signal transduction pathways defines two types of serum response factor target gene

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7 January 2021

Transport between the cell nucleus and the cytoplasm

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7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 January 2021

Transcriptional regulation by extracellular signals: mechanisms and specificity

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7 January 2021

Functional analysis of a growth factor-responsive transcription factor complex

1 reference

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7 January 2021

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

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7 January 2021

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

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7 January 2021

Tyrosine kinase inhibition: an approach to drug development

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7 January 2021

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

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7 January 2021

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes

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7 January 2021

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

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7 January 2021

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1 reference

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7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

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7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

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7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Regulation of transcriptional activation domain function by ubiquitin

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Filamin associates with Smads and regulates transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Cell signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

TGF-beta signaling: positive and negative effects on tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Formation of a stable heterodimer between Smad2 and Smad4

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Crystal Structure of a Phosphorylated Smad2

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Importin beta mediates nuclear translocation of Smad 3

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900585-3

7 January 2021

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.

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7 January 2021

Untangling the ErbB signalling network

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7 January 2021

10.1016/S1097-2765(02)00585-3

Identifiers

DOI

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7 November 2017

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