Structural basis for specificity of TGFβ family receptor small molecule inhibitors (Q27674793)

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Language	Label	Description	Also known as
English	Structural basis for specificity of TGFβ family receptor small molecule inhibitors	scientific article

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instance of

scholarly article

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title

Structural basis for specificity of TGFβ family receptor small molecule inhibitors (English)

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main subject

cell biology

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author

Frank Sicheri

series ordinal

4

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Elton Zeqiraj

series ordinal

2

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Laurent David

object named as

Laurent David

series ordinal

6

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Derek F Ceccarelli

object named as

Derek F Ceccarelli

series ordinal

3

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Jeffrey L. Wrana

series ordinal

5

object named as

Jeffrey L Wrana

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author name string

Abiodun A Ogunjimi

series ordinal

1

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publication date

February 2012

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published in

Cellular Signalling

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volume

24

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issue

2

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page(s)

476-83

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cites work

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

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20 March 2017

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

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20 March 2017

Molecular replacement with MOLREP

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20 March 2017

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

Signal transduction by the TGF-beta superfamily

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20 March 2017

Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

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20 March 2017

A quantitative analysis of kinase inhibitor selectivity

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20 March 2017

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

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20 March 2017

Targeting cancer with small molecule kinase inhibitors

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7 April 2017

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7 April 2017

Regulation of protein kinases; controlling activity through activation segment conformation

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7 April 2017

The specificities of small molecule inhibitors of the TGFß and BMP pathways

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29 September 2017

Through the "gatekeeper door": exploiting the active kinase conformation

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29 September 2017

Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease

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29 September 2017

An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer

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29 September 2017

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model

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29 September 2017

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice

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29 September 2017

Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis

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29 September 2017

Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.

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29 September 2017

Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI).

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29 September 2017

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

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29 September 2017

A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.

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2 June 2018

The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor

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2 June 2018

The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta

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27 November 2018

Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor

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27 November 2018

Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

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27 November 2018

A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src

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12 December 2020

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Identifiers

DOI

10.1016/J.CELLSIG.2011.09.027

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PMC publication ID

4490768

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PubMed publication ID

21983015

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ResearchGate publication ID

51702605

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