The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway (Q42509261)

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Language	Label	Description	Also known as
English	The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway	scientific article

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scholarly article

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Europe PubMed Central

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1 November 2017

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway (English)

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Europe PubMed Central

PubMed publication ID

1 November 2017

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Mireia Niso-Santano

2

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Europe PubMed Central

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1 November 2017

Rubén Gómez-Sánchez

3

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Europe PubMed Central

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1 November 2017

José M. Fuentes

11

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1 November 2017

Rosario Sanchez-Pernaute

object named as

Rosario Sanchez-Pernaute

9

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José Manuel Bravo-San Pedro

1

object named as

José M Bravo-San Pedro

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1 November 2017

author name string

Elisa Pizarro-Estrella

4

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1 November 2017

Ana Aiastui-Pujana

5

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1 November 2017

Ana Gorostidi

6

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Europe PubMed Central

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1 November 2017

Vicente Climent

7

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Europe PubMed Central

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1 November 2017

Rakel López de Maturana

8

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Europe PubMed Central

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1 November 2017

Adolfo López de Munain

10

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Europe PubMed Central

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1 November 2017

Rosa A González-Polo

12

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1 November 2017

publication date

8 July 2012

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1 November 2017

Cellular and Molecular Life Sciences

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1 November 2017

70

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Europe PubMed Central

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1 November 2017

1

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Europe PubMed Central

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1 November 2017

121-136

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Europe PubMed Central

PubMed publication ID

1 November 2017

Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Autophagy and neurodegeneration: when the cleaning crew goes on strike

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Identification of the autophosphorylation sites of LRRK2.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

LRRK2 regulates synaptic vesicle endocytosis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Development by self-digestion: molecular mechanisms and biological functions of autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Silencing DJ-1 reveals its contribution in paraquat-induced autophagy.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Autophagy: dual roles in life and death?

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

The autophagosomal-lysosomal compartment in programmed cell death

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Autophagy and the Integrated Stress Response

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Autophagy in the eukaryotic cell

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

The IKK complex contributes to the induction of autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Diagnostic criteria for Parkinson disease

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Molecular pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Interaction between α-synuclein and other proteins in neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

alpha-synuclein and LRRK2: partners in crime

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Alpha-synuclein and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Pathological roles of α-synuclein in neurological disorders

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

21 January 2018

Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22773119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al

1 reference

https://pubmed.ncbi.nlm.nih.gov/22773119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy and cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22773119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22773119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00018-012-1061-Y

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

ResearchGate publication ID

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