Stem-cell biotechnology articles from across Nature Portfolio

Establishment and characterization of a spontaneously immortalized fish muscle stem cell line (EfMS) from brown-marbled grouper with undiminished stemness and differentiation potential for the production of cell-cultured fish meat.

Acoustic pressure generated by low-intensity focused ultrasound can activate the mechanosensitive RET signalling pathway and cell proliferation, as shown in mouse colonic crypts ex vivo and in vivo.

Extracellular vesicles from adipose-derived rat stromal cells embedded in a thermoresponsive gel display pro-regenerative and immunomodulatory effects, resulting in the healing of colorectal anastomosis in rats.

The enhanced observability of bilaterally accessible gastrointestinal organoid-derived monolayers facilitates the study of parasite infection of the gut.

Organoid research can be limited by the lack of methods for producing uniformly mature organoids. Here, the authors present UniMat, an organoid culture platform featuring a 3D geometrically-engineered permeable membrane, which produces uniform and mature organoids by providing both geometrical constraints and unrestricted supply of factors.

An article in Science Robotics presents a wireless bioelectronic robot that integrates living motor neurons and cardiomyocytes to power movement.

Substrates with concave curvatures resembling those found in the developing embryo mechanically revert mouse and human pluripotent stem cells into a naivety-like state.

Commercializing cultured meat requires cost reduction and quality improvement. Microbial cell factories can produce cost-effective and high-quality raw materials for cultured meat production.

A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes.

Satellite cells, the stem cells of skeletal muscle, are responsible for muscle development and regeneration. Although low in abundance, satellite cells can be isolated from muscle but cannot be propagated successfully in culture in numbers needed for therapeutic use. We developed a method to generate cells with satellite cell characteristics from skeletal muscle organoid cultures.

An article in Nature reports the generation of human chimeric brain organoids that integrate cells from multiple donors.