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Stem cells

A developmental route to hematopoietic stem cells

Nature Biotechnology (2024)Cite this article

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A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes.

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Fig. 1: Recently published protocols for the generation of hematopoietic stem cells from human pluripotent stem cells in vitro.

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Authors and Affiliations

  1. MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom

    Adam C. Wilkinson & Marella F. T. R. de Bruijn

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  1. Adam C. Wilkinson
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  2. Marella F. T. R. de Bruijn
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Corresponding authors

Correspondence to Adam C. Wilkinson or Marella F. T. R. de Bruijn.

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The authors declare no competing interests.

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Wilkinson, A.C., de Bruijn, M.F.T.R. A developmental route to hematopoietic stem cells. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02398-7

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