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    To celebrate the 2024 Nobel Prize in Chemistry awarded for computational protein design and protein structure prediction, we have compiled a selection of our Protocols and Tutorials showcasing the diverse applications of computational structure prediction methods. The articles cover a wide range of topics including protein structure prediction and refinement, docking, predicting intrinsic disorder in proteins, virtual screening, strategies to analyse off-target effects of programmable nucleases, antibody modeling and epitope mapping.

    Image: Du, Z., Su, H., Wang, W. et al. The trRosetta server for fast and accurate protein structure prediction. Nat Protoc 16, 5634–5651 (2021). https://doi.org/10.1038/s41596-021-00628-9

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    The 2024 Nobel Prize in Chemistry has been awarded to David Baker “for computational protein design” and to Demis Hassabis and John M. Jumper “for protein structure prediction”.

    Image: Springer Nature/The Nobel Foundation/Imagesource

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    The Nobel Prize in Physics 2024 has been awarded to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks”.

    Image: Springer Nature/The Nobel Foundation/Imagesource

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    A collection of Protocols and Tutorials covering a variety of approaches for the optical clearing of tissue samples

    Image: Li, W., Germain, R.N. & Gerner, M.Y. High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging. Nat Protoc 14, 1708–1733 (2019).

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    Detailed method reporting is essential for research reproducibility and trust in published results.

    Image: Sam Whitham

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    A collection of Protocols covering a wide range of optogenetic and non-genetic procedures that allow the stimulation of neuronal cell populations using optical, closed-loop and ultrasonic approaches.

    Image: Sam Witham

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    A collection of Protocols and Tutorials covering the fabrication and use of implantable bioelectronic devices which enable the recording of electrophysiological parameters and the interrogation of neural circuits in animals and humans

    Image: Coughlin, B. et al. Nat Protoc (2023). https://doi.org/10.1038/s41596-023-00871-2

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    Chemistry has always had a central role in the provision of food and energy, materials and medicines. Recent years have increasingly seen chemistry research move towards environmentally friendly, sustainable products and processes.

    Image: Erin Dewalt, Lauren Robinson, David Schilter, Rachael Tremlett

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    Selected, recent articles from across the Nature Portfolio that document the recent progress in understanding the biology of EV-mediated cell–cell communication and advances in clinical translation of EVs.

    Image: Vicky Summersby

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    This Collection provides an overview of current progress in developing targeted genome editing technologies, including a selection of protocols for using and adapting these tools in your own lab.

    Image: LuckyStep48 / Alamy Stock Vector